{"id":3203,"date":"2023-07-25T12:22:56","date_gmt":"2023-07-25T12:22:56","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=3203"},"modified":"2023-07-28T11:10:44","modified_gmt":"2023-07-28T11:10:44","slug":"west-african-journal-of-pharmacy-2022-33-2-32-46","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2022-33-2-32-46\/","title":{"rendered":"West African Journal of Pharmacy (2022) 33 (2) 32 – 46"},"content":{"rendered":"\t\t
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Haematopoiesis-stimulating activity of Tapinanthus globiferus on cyclophosphamide-induced immunosuppression in albino rats.<\/strong>
Olusegun S. Ajala, Sefunmi P. Akinseye
Department of Pharmaceutical Chemistry, University of Lagos, Nigeria
Corresponding author: Sefunmi P. Akinseye
Email: spakunic@gmail.com Telephone : +2348137992001<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/strong> Immunostimulation is a valuable but under-utilised alternative to conventional antimicrobial and\u00a0anticancer chemotherapies. Optimum immunostimulation is a function of adequate haematopoiesis as against\u00a0mere leucocyte proliferation. The immunostimulatory potentials of the African mistletoe, Tapinanthus globiferus,\u00a0could be conjectured based on morphological and chemotaxonomic association with its European counterpart
Viscum album, an established immunostimulant.<\/p>

Objective:<\/b> This study investigated the phytochemicals in the methanol leaf extract of Tapinanthus globiferus, its\u00a0acute toxicity, and stimulatory effects on White Blood Cell (WBC), Red Blood Cell (RBC), and Platelet (PLT) counts.<\/p>

Methods:<\/b> Crude methanol leaf extract of T. globiferus was screened for phytochemical constituents according to\u00a0established procedures. Immunosuppression was induced (using 30mg\/Kg cyclophosphamide) in twenty-five\u00a0albino male rats randomly and equally distributed into five groups (1-5). Extract was administered for 14 days at 50\u00a0mg\/Kg, 100 mg\/Kg, and 150 mg\/Kg doses to groups 3, 4 and 5 respectively, groups 1 and 2 receiving 5% tween 80\u00a0and levamisole respectively instead. Blood sample was collected from each rat before and after\u00a0immunosuppression, and after the 14-day treatment regimen, followed by analysis for total and differential white\u00a0WBC, RBC, and PLT counts.<\/p>

Results:<\/b> Saponins, reducing sugars, cardiac glycosides, phenolic compounds, tannins, flavonoids, steroids,\u00a0anthraquinones, and terpenoids were confirmed present. There was a statistically significant increase in each of\u00a0the total and differential WBC, RBC, and PLT counts compared to the negative control (p < 0.05).<\/p>

Conclusion:<\/b> Tapinanthus globiferus possesses immunostimulatory, erythropoietic, and thrombopoietic activities.<\/p>

Keywords:<\/b> Immunosuppression, immunostimulatory activity, cyclophosphamide, mistletoe, Tapinanthus\u00a0globiferus, haematological evaluation<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Haematopoiesis-stimulating activity of Tapinanthus globiferus on cyclophosphamide-induced immunosuppression in albino rats.Olusegun S. Ajala, Sefunmi P. AkinseyeDepartment of Pharmaceutical Chemistry, University of Lagos, NigeriaCorresponding author: Sefunmi P. AkinseyeEmail: spakunic@gmail.com Telephone : +2348137992001 ABSTRACT Background: Immunostimulation is a valuable but under-utilised alternative to conventional antimicrobial and\u00a0anticancer chemotherapies. Optimum immunostimulation is a function of adequate haematopoiesis as against\u00a0mere […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[1],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/3203"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=3203"}],"version-history":[{"count":6,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/3203\/revisions"}],"predecessor-version":[{"id":3667,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/3203\/revisions\/3667"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=3203"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=3203"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=3203"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}