{"id":3699,"date":"2022-11-22T08:48:39","date_gmt":"2022-11-22T08:48:39","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=3699"},"modified":"2023-07-07T17:04:39","modified_gmt":"2023-07-07T17:04:39","slug":"west-african-journal-of-pharmacy-2022-33-1-23-32","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2022-33-1-23-32\/","title":{"rendered":"West African Journal of Pharmacy (2022) 33 (1) 23 – 32"},"content":{"rendered":"\t\t
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Drug prescribing and potential drug-drug interactions at the paediatric unit of a secondary health facility in<\/b><\/p>

Southern-Ijaw Local Government Area, Niger Delta Region, Nigeria<\/b><\/p>

\u00a0<\/b><\/p>

Kehinde A. Ganiyu, Azibapuowili O. Mac-Moses, Adebukola A. Sounyo<\/p>

Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Niger Delta University,<\/p>

\u00a0<\/p>

Wilberforce Island, Bayelsa State, Nigeria<\/p>

Corresponding author: Kehinde A. Ganiyu<\/p>

Email: pharmkenny@gmail.com<\/p>

Phone.: +2347031380705<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background<\/b>: Drug interactions resulting from multidrug prescribing can be desirable and\/or non-desirable.<\/p>

Objective:<\/b>\u00a0To assess drug prescribing and potential drug-drug interactions at the paediatric unit of Amassoma\u00a0General Hospital in the Southern-Ijaw Local Government Area, Bayelsa State, Niger Delta Area of Nigeria.<\/span><\/p>

Methods:<\/b>\u00a0Retrospective evaluation of randomly selected 227 case notes of paediatric patients (aged, <12 years),\u00a0who attended clinics at the study center from January 01 to December 31, 2020 was carried out. Pertinent data\u00a0<\/span>collected on diseases, medications prescribed, selected prescribing indicators, and potential drug-drug\u00a0<\/span>interactions (pDDIs) identified were presented descriptively, in simple percentages, mean, and median as\u00a0<\/span>appropriate. Where necessary, average values were compared using student-t test, and a p-value less than 0.05\u00a0<\/span>was considered statistically significant.<\/span><\/p>

Results:<\/b>\u00a0Each of the paediatric patients presented with average of 2.07 \u00b1 0.79 diseases per encounter, and majority\u00a0(252, 56.2%) were treated for infections. Average of 4.37 \u00b1 1.73 drugs were ordered per encounter, and anti-<\/span>infectives (423, 42.8%) were the most prescribed. All selected prescribing indicators were not within referenced\u00a0<\/span>standards, excluding encounters with injections prescribed (19.2%). A total of 160 (70.5%) of all 227 prescriptions\u00a0<\/span>vetted contained at least a pDDI. In all, average of 1.35 \u00b1 1.28 pDDIs were observed per prescription, of which 0.93\u00a0<\/span>\u00b1 0.82 and 0.42 \u00b1 0.77 (p < 0.05) were desirable and non-desirable, respectively. Adverse events (72, 74.2%) and\u00a0<\/span>reduction in effectiveness (25, 25.8%) of medication therapy constituted the main potential clinical consequences\u00a0<\/span>of non-desirable pDDIs identified.<\/span><\/p>

Conclusion:<\/b>\u00a0The paediatric patients seen at the study center routinely present with infections, and were mostly\u00a0prescribed anti-infective agents. Drug prescribing practice observed was grossly suboptimal and there were\u00a0<\/span>several cases of non-desirable pDDIs.<\/span><\/p>

Keywords:\u00a0<\/b>Bayelsa State, Drug Prescribing, Niger Delta Area, Potential Drug-drug Interaction, Paediatric Patients,\u00a0Southern Ijaw Local Government Area.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Drug prescribing and potential drug-drug interactions at the paediatric unit of a secondary health facility in Southern-Ijaw Local Government Area, Niger Delta Region, Nigeria \u00a0 Kehinde A. Ganiyu, Azibapuowili O. Mac-Moses, Adebukola A. Sounyo Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmacy, Niger Delta University, \u00a0 Wilberforce Island, Bayelsa State, Nigeria Corresponding author: […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[209],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/3699"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=3699"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/3699\/revisions"}],"predecessor-version":[{"id":3705,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/3699\/revisions\/3705"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=3699"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=3699"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=3699"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}