{"id":4113,"date":"2023-07-06T13:27:44","date_gmt":"2023-07-06T13:27:44","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4113"},"modified":"2023-07-22T13:37:10","modified_gmt":"2023-07-22T13:37:10","slug":"west-african-journal-of-pharmacy-2021-32-1-182-194","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2021-32-1-182-194\/","title":{"rendered":"West African Journal of Pharmacy (2021) 32 (1) 182 – 194"},"content":{"rendered":"\t\t
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Evaluation of antioxidant and antibacterial activities of extracts of Celtis philippensis Blanco (Ulmaceae) on\u00a0<\/b>multidrug resistant wound pathogens<\/b><\/p>

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Philip A. Idowu , Faith J. Afolayan , Charles O. Olaiya<\/p>

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1Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Nigeria.<\/p>

2Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Nigeria.<\/p>

\u00a0<\/p>

Corresponding author: Philip Adegboyega Idowu,<\/p>

E-mail: igboyega@yahoo.com; Phone: +2348033524399<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background: Antimicrobial resistance among wound pathogens is increasing, creating the need to search for new\u00a0and effective agents, especially among medicinal plants used to treat wounds traditionally. There is a worldwide\u00a0<\/span>search for medicinal plants with good antibacterial and antioxidant activities to treat infected wounds.<\/span><\/p>

Objectives:<\/b> Celtis philippensis used locally to treat infections was evaluated for its antioxidant and antibacterial\u00a0activities against multidrug resistant (MDR) pathogens from infected wounds from three Nigerian hospitals.<\/span><\/p>

Methods:<\/b> Methanol extract of C. philippensis stem was tested at 20 and 10mg\/ml on 32 wound pathogens\u00a0comprising of Staphylococcus aureus (14), Pseudomonas aeruginosa (10) and Klebsiella pneumoniae (8). Agar\u00a0<\/span>diffusion methods was used to determine antibiogram and susceptibility to extracts while agar dilution method\u00a0<\/span>was used to determine minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations\u00a0<\/span>(MBC). The antioxidant potential was evaluated by four methods: catalase activity, lipid peroxidation inhibition,\u00a0<\/span>hydrogen peroxide radical scavenging activity and DPPH radical scavenging activity. Statistical analysis was done\u00a0<\/span>using ANOVA.<\/span><\/p>

Results:<\/b> Antibiogram showed that the test organisms were MDR bacteria. The extract was active on all the tested\u00a0pathogens with zones of inhibition of between 13-35mm. The MIC and MBC values ranged between 0.625-<\/span>5mg\/ml for all the test organisms and MIC index indicated bactericidal activity. The methanol extract showed good\u00a0<\/span>antioxidant activity (lipid peroxidation inhibition and catalase activity) comparable with ascorbic acid standard.<\/span><\/p>

Conclusion:<\/b> Antioxidant and antibacterial activities of Celtis philippensis justified its folkloric use in treating\u00a0infections. Moreover, good activity on multidrug resistant wound pathogens highlights its potentials as a source of\u00a0<\/span>antimicrobial agents to treat wounds infected with MDR pathogens.<\/span><\/p>

Keywords:<\/b> Celtis philippensis, multidrug resistant pathogens, antibacterial, antioxidant, wounds.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Evaluation of antioxidant and antibacterial activities of extracts of Celtis philippensis Blanco (Ulmaceae) on\u00a0multidrug resistant wound pathogens \u00a0 Philip A. Idowu , Faith J. Afolayan , Charles O. Olaiya \u00a0 1Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Ibadan, Nigeria. 2Department of Biochemistry, Faculty of Basic Medical Sciences, University of Ibadan, Nigeria. \u00a0 Corresponding […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[229],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4113"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4113"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4113\/revisions"}],"predecessor-version":[{"id":4119,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4113\/revisions\/4119"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4113"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4113"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4113"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}