{"id":4120,"date":"2023-07-05T13:38:26","date_gmt":"2023-07-05T13:38:26","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4120"},"modified":"2023-07-22T13:46:16","modified_gmt":"2023-07-22T13:46:16","slug":"west-african-journal-of-pharmacy-2021-32-1-195-204","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2021-32-1-195-204\/","title":{"rendered":"West African Journal of Pharmacy (2021) 32 (1) 195 – 204"},"content":{"rendered":"\t\t
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Phytochemical, antioxidant and antimicrobial studies of partitioned fractions of Lannea kerstingii Engl.\u00a0<\/b>and K. Krause (Anarcadiaceae)<\/b><\/p>

\u00a0<\/b><\/p>

Ngaitad S. Njinga, Susan M. David, Abiodun O. Shittu, Bilqis A. Lawal, Ronke H. Bello,\u00a0Francis A.U. Attah, Sukurat O. Usman, Abdulrasheed A. Abdullahi, and Moji T. Bakare-Odunola<\/span><\/p>

1Department of Pharmaceutical and Medicinal Chemistry, University of Ilorin, Nigeria<\/p>

2Department of Pharmaceutical Microbiology and Biotechnology, University of Ilorin, Ilorin, Nigeria<\/p>

3Department of Pharmaceutics and Industrial Pharmacy, University of Ilorin, Ilorin, Nigeria<\/p>

4Department of Pharmacognosy and Drug Development, University of Ilorin, Ilorin, Nigeria<\/p>

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Corresponding author: Ngaitad S. Njinga<\/p>

Email: ngastanjin@yahoo.com; Phone: +234 <\/b>7064933604<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Antimicrobial resistance is a serious threat to global public health and requires actions like\u00a0the development of new antimicrobial with significant activities over existing drugs.<\/span><\/p>

Objectives:<\/b> This study aims at investigating the phytochemical, antioxidant and antimicrobial\u00a0potentials of partitioned fractions of Lannea kerstingii.<\/span><\/p>

Methods:<\/b> A quantitative phytochemistry of chloroform, ethyl acetate, acetone and methanol fractions\u00a0of L. kerstingii for total flavonoid, phenol and alkaloid were done using standard method; antioxidant\u00a0<\/span>and antimicrobial activity were determined using 1,1-Diphenyl-2-picrylhydrazyl and agar diffusion\u00a0<\/span>method respectively.<\/span><\/p>

Results:<\/b> The chloroform fraction contained only alkaloid (11%) and steroids while all the other fractions\u00a0contained phenolic compounds in the range 0.43 to 0.67 mg\/g garlic acid. The total flavonoid content\u00a0<\/span>ranged from 0.43 to 0.67 mg\/g of quercetin. The total flavonoid in the ethyl acetate was significantly\u00a0<\/span>different from that of the methanol fraction but not with the acetone fraction. The acetone fraction\u00a0<\/span>showed highest antioxidant activity (60.4%) at 0.05 mg\/mL though not as comparable to vitamin C. The\u00a0<\/span>ethyl acetate showed high antimicrobial activity as it was active against most of the organisms tested\u00a0<\/span>upon and zone of inhibition ranged from 13\u00b10.02 to 29\u00b10.1 mm. The acetone fraction was active only\u00a0<\/span>against T. mentagrophytes while the methanol fraction showed no activity.<\/span><\/p>

Conclusion:<\/b> The antioxidant and antimicrobial activities may be due to the presence of flavonoids, as\u00a0well as the presence of tannins and terpenoids present in the different fractions. This makes the ethyl\u00a0<\/span>acetate fraction a good source of antioxidant and antimicrobial agent.<\/span><\/p>

Keywords:<\/b> Quantitative phytochemistry, Antimicrobial assay, Antioxidant assay, Lannea kerstingii<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Phytochemical, antioxidant and antimicrobial studies of partitioned fractions of Lannea kerstingii Engl.\u00a0and K. Krause (Anarcadiaceae) \u00a0 Ngaitad S. Njinga, Susan M. David, Abiodun O. Shittu, Bilqis A. Lawal, Ronke H. Bello,\u00a0Francis A.U. Attah, Sukurat O. Usman, Abdulrasheed A. Abdullahi, and Moji T. Bakare-Odunola 1Department of Pharmaceutical and Medicinal Chemistry, University of Ilorin, Nigeria 2Department of […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[229],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4120"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4120"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4120\/revisions"}],"predecessor-version":[{"id":4126,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4120\/revisions\/4126"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4120"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4120"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4120"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}