{"id":4141,"date":"2023-07-03T14:13:35","date_gmt":"2023-07-03T14:13:35","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4141"},"modified":"2023-07-22T14:23:18","modified_gmt":"2023-07-22T14:23:18","slug":"west-african-journal-of-pharmacy-2021-32-1-215-218","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2021-32-1-215-218\/","title":{"rendered":"West African Journal of Pharmacy (2021) 32 (1) 215 – 218"},"content":{"rendered":"\t\t
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Haematological effects of aqueous stem extract of Croton membranaceus in male Sprague-Dawley rats<\/b><\/p>

Afriyie Daniel , Ameyaw Elvis , Appiah-Oppong Regina<\/p>

\u00a0<\/p>

1Biomedical Sciences Department, University of Capecoast, Ghana.<\/p>

2Ghana Police Hospital, Pharmacy Department, Accra-Ghana<\/p>

3Noguchi Memorial Institute for Medical Research, Accra, Ghana<\/p>

dspdan77@yahoo.com\/acpdan77@gmail.com<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background<\/b>: Roots of Croton membranaceus has been used for decades for management of prostate enlargement <\/span>for decades in Ghana, and recently with scientific proofs. <\/span>Haematopoietic system is an important index of<\/span>physiological status in man and animals. Assay and <\/span>interpretation of haematological parameters in <\/span>experimental animals during the study of a potential drug <\/span>or extract is a common practice in toxicological studies. <\/span>Currently, the stem is being added to the roots for <\/span>management of prostate enlargement in Ghana without <\/span>scientific evidence.<\/span><\/p>\n

Objective: <\/b>To study the effect of aqueous stem extract of Croton membranaceus (CMASE) on the haematological <\/span>indices of male Sprague-Dawley (SD) rats.<\/span><\/p>\n

Methods:<\/b> A total of 24 male SD rats were divided into 4 groups and administered distilled water (control), CMASE <\/span>doses of 30, 150 and 300 mg\/kg by oral gavage for 60 days. <\/span>At the end study, blood obtained by cardiac puncture after <\/span>anesthesia was analyzed. Results were using one way <\/span>analysis of variance (ANOVA) with Graphpad prism 6, and significance set at p < 0.05. Ethical clearance was obtained <\/span>for study (UG-IACUC 003\/18-19).<\/span><\/p>\n

Results:<\/b> No statistical significant differences was observed in haematological indices: haemoglobin concentration <\/span>(HB),red blood cells (RBC),mean corpuscular haemoglobin <\/span>(MCH), mean corpuscular volume (MCV),mean corpuscular <\/span>haemoglobin concentration(MCHC),mean corpuscular <\/span>haemoglobin (MCH), white blood count (WBC) levels in the <\/span>treated groups compared to control. Also, effects of CMASE <\/span>on these indices were mostly in non dose-dependent <\/span>pattern. CMASE caused non-significant marked elevation of <\/span>platelets levels of compared to the control group.<\/span><\/p>\n

Conclusion:<\/b> CMASE does not have potential to induce anemia, leucopenia nor leukocytosis but could cause <\/span>thrombocytosis.<\/span><\/p>\n

Keywords:<\/b> Haematological indices, stem extract, C. membranaceus, rats.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Haematological effects of aqueous stem extract of Croton membranaceus in male Sprague-Dawley rats Afriyie Daniel , Ameyaw Elvis , Appiah-Oppong Regina \u00a0 1Biomedical Sciences Department, University of Capecoast, Ghana. 2Ghana Police Hospital, Pharmacy Department, Accra-Ghana 3Noguchi Memorial Institute for Medical Research, Accra, Ghana dspdan77@yahoo.com\/acpdan77@gmail.com ABSTRACT Background: Roots of Croton membranaceus has been used for decades for management […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[229],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4141"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4141"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4141\/revisions"}],"predecessor-version":[{"id":4147,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4141\/revisions\/4147"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4141"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4141"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4141"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}