{"id":4187,"date":"2023-07-21T15:30:44","date_gmt":"2023-07-21T15:30:44","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4187"},"modified":"2023-07-22T16:11:42","modified_gmt":"2023-07-22T16:11:42","slug":"west-african-journal-of-pharmacy-2020-31-1-6-14","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2020-31-1-6-14\/","title":{"rendered":"West African Journal of Pharmacy (2020) 31 (1) 6 – 14"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

Understanding the molecular tricks of SARS-CoV-2<\/b><\/p>

\u00a0<\/b><\/p>

\u00a0Richard J. Kutshik , Ishaya Y. Longdet , Kennedy I. Amagon , Bukata B. Bukar , Noel N. Wannang ,\u00a0Jacob A. Kolawole , Kakjing D. Falang , Ukpe Ajima , James G. Damen , Yusuf A. Agabi,\u00a0<\/span>Simji S. Gomerep , Ismaila Shittu , Stephen D. Davou<\/span><\/p>

\u00a0<\/p>

1Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Jos, Plateau State, Nigeria.<\/p>

2Department of Biochemistry, Faculty of Basic Medical Sciences, University of Jos, PMB 2084,\u00a0Jos, Plateau State, Nigeria.<\/span><\/p>

\u00a0<\/p>

3Department of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, University of Jos,\u00a0PMB 2084, Jos, Plateau State, Nigeria.<\/span><\/p>

\u00a0<\/p>

4Department of Pharmaceutical & Medicinal Chemistry, Faculty of Pharmaceutical Sciences,\u00a0University of Jos, PMB 2084, Jos, Plateau State, Nigeria.<\/span><\/p>

\u00a0<\/p>

5Department of Medical Laboratory Sciences, Faculty of Health Sciences and Technology,\u00a0University of Jos, PMB 2084, Jos, Plateau State, Nigeria.<\/span><\/p>

\u00a0<\/p>

6Virology Unit, Department of Microbiology, Faculty of Natural Sciences, University of Jos,\u00a0PMB 2084, Jos, Plateau State, Nigeria.<\/span><\/p>

\u00a0<\/p>

7Infectious Diseases Unit, Department of Medicine, Faculty of Clinical Sciences, University of Jos,\u00a0<\/span>PMB 2084, Jos, Plateau State, Nigeria.<\/span><\/p>

\u00a0<\/p>

8National Veterinary Research Institute, Vom, Plateau State, Nigeria.<\/p>

9Plateau State Ministry of Health, Jos, Nigeria.<\/p>

\u00a0<\/p>

Corresponding author: Richard J. Kutshik<\/p>

Email: kutshikj@unijos.edu.ng, Phone: +2348098664834<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t

ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

Background:<\/b> The SARS CoV-2 causes Coronavirus disease 2019 resulting in 27,486,960 confirmed cases, 894,983\u00a0deaths in 216 countries. Being a novel virus, understanding its nature and behaviours becomes imperative.<\/span><\/p>

Objective: <\/b>To discuss molecular tricks that coronaviruses employ to maneuver through membranes, escape\u00a0defense systems and commandeer metabolic machineries.<\/span><\/p>

Methods:<\/b> Literature search was carried out using various databases based on keywords and only English articles\u00a0with available data up to 25th June, 2020 were included.<\/span><\/p>

Results:<\/b> The first tricky task is SARS-CoV-2 enters the host cell through ACE2, involving its spike glycoprotein and\u00a0serine protease TMPRSS2. As it enters the host cell it hijack membranes inside cells and turn them into virus\u00a0<\/span>factories where it builds molecular machinery called replicase complexes to copy their genetic code, which is\u00a0<\/span>needed for the next generation of virus particles. Viruses including coronaviruses have evolved different strategies\u00a0<\/span>to produce capped mRNA as a molecular trick to synthesise their proteins efficiently and also escape the host cell’s\u00a0<\/span>innate immune response. The viruses steal and repurpose proteins from their host cell that will assist in the\u00a0<\/span>copying process. SARS coronavirus protein called “nsp1” causes the breakdown of biochemical messages that\u00a0<\/span>normally prompt the production of a protein critical to defending the body against viruses. The SARS nsp1 protein\u00a0<\/span>degrades the messenger RNA instructions sent from DNA to make interferon beta, which is crucial to host\u00a0<\/span>immunity.<\/span><\/p>

Conclusion:<\/b> Novel SARS-CoV-2 with 29 proteins spreads and impact the world in impeccable ways.<\/p>

KeyWords:<\/b> SARS-CoV-2, ACE2, replicase, nsp1, mRNA<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Understanding the molecular tricks of SARS-CoV-2 \u00a0 \u00a0Richard J. Kutshik , Ishaya Y. Longdet , Kennedy I. Amagon , Bukata B. Bukar , Noel N. Wannang ,\u00a0Jacob A. Kolawole , Kakjing D. Falang , Ukpe Ajima , James G. Damen , Yusuf A. Agabi,\u00a0Simji S. Gomerep , Ismaila Shittu , Stephen D. Davou \u00a0 1Plateau […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[210],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4187"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4187"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4187\/revisions"}],"predecessor-version":[{"id":4193,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4187\/revisions\/4193"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4187"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4187"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4187"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}