{"id":4194,"date":"2023-07-20T15:43:41","date_gmt":"2023-07-20T15:43:41","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4194"},"modified":"2023-07-22T16:12:53","modified_gmt":"2023-07-22T16:12:53","slug":"west-african-journal-of-pharmacy-2020-31-1-15-24","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2020-31-1-15-24\/","title":{"rendered":"West African Journal of Pharmacy (2020) 31 (1) 15 – 24"},"content":{"rendered":"\t\t
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Anti-nociceptive and antipyretic activities of CoV-Pla 3 extract: relevance on symptomatic\u00a0<\/b>treatment of Covid-19 Disease<\/b><\/span><\/p>

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Bukata B. Bukar , Kakjing D. Falang , Kennedy I. Amagon , Yusuf A. Agabi , Richard J. Kutshik,\u00a0Ajima Ukpe, Yohanna L. Ishaya, Simji S. Gomerep , Stephen D. Davou, Ismaila Shittu,\u00a0<\/span>James G. Damen , Noel N. Wannang , Jacob A. Kolawole<\/span><\/p>

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1Plateau State Research Committee on Covid-19 and Other Infectious Diseases, Government House, Rayfield, Jos.<\/p>

2Department of Pharmacology and Toxicology, University of Jos, Jos<\/p>

3Virology Unit, Department of Microbiology, University of Jos, Jos<\/p>

4Department of Biochemistry, University of Jos, Jos<\/p>

5Department of Pharmaceutical and Medicinal Chemistry, University of Jos, Jos<\/p>

6Infectious Disease Unit, Department of Medicine, University of Jos<\/span><\/p>

7Plateau State Ministry of Health, Jos<\/p>

8National Veterinary Research Institute (NVRI), Vom, Plateau state<\/p>

9 Department of Medical Laboratory Sciences, University of Jos, Jos<\/p>

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Corresponding author: Bukata B. Bukar<\/p>

Email: bukata33@yahoo.com, Phone: +2348036183979<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> There is an urgent need to search for effective remedies against COVID-19 from the rich and extensive\u00a0flora of Africa.<\/span><\/p>

Objectives:<\/b> The aim of this study was to evaluate the anti-nociceptive and anti-pyretic activities of the methanol\u00a0extract of a herbal combination product, Cov-Pla3 in experimental animals.<\/span><\/p>

Methods:<\/b> Animal models of nociception and hyperthermia including acetic acid-induced contortion, hot-plate-induced nociception, egg albumin-induced paw edema and Brewer’s yeast-induce hyperthermia were adopted.<\/span><\/p>

Results:<\/b> The results revealed that the Cov-Pla3 extract at all the doses used increased the reaction time in a non-significant manner (p > 0.05). However, the increase in reaction time at doses of the extract was significant\u00a0<\/span>compared to the baseline (p <0.05). The results also showed that Cov-Pla3 extract at the dose of 125 mg\/kg at 90\u00a0<\/span>minutes after administration had the highest anti-nociceptive effect of 49.73 % followed by 46.70 % at the dose of\u00a0<\/span>500 mg\/kg at same period.\u00a0<\/span>It was also shown that the extract significantly reduced acetic acid-contortions at a dose of 500 mg\/kg (p < 0.05) with\u00a0<\/span>corresponding inhibition of 73 %. The extract at all the doses used significantly decreased paw edema compared to\u00a0<\/span>baseline after 180 minutes of administration (p < 0.05). The anti-pyretic test indicated that Cov-Pla3 significantly\u00a0<\/span>reduced temperature at 125 mg and 500 mg\/kg after 4 hours of administration (p< 0.05). In conclusion, Cov-Pla3\u00a0<\/span>possesses a combination of analgesic, anti-inflammatory and antipyretic activities.<\/span><\/p>

Conclusion:<\/b> This scientific evidence, in addition to its safety profile from the LD50 of above 5000 mg\/kg, justifies its\u00a0recommendation for clinical trial use in Covid-19 patients with severe symptoms.<\/span><\/p>

Keywords:<\/b> Phytotherapy, Covid-19, Nociception, Hyperthermia, Cov-Pla3, Coronavirus<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Anti-nociceptive and antipyretic activities of CoV-Pla 3 extract: relevance on symptomatic\u00a0treatment of Covid-19 Disease \u00a0 Bukata B. Bukar , Kakjing D. Falang , Kennedy I. Amagon , Yusuf A. Agabi , Richard J. Kutshik,\u00a0Ajima Ukpe, Yohanna L. Ishaya, Simji S. Gomerep , Stephen D. Davou, Ismaila Shittu,\u00a0James G. Damen , Noel N. Wannang , Jacob […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[210],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4194"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4194"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4194\/revisions"}],"predecessor-version":[{"id":4200,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4194\/revisions\/4200"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4194"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4194"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4194"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}