{"id":4215,"date":"2023-07-19T16:14:11","date_gmt":"2023-07-19T16:14:11","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4215"},"modified":"2023-07-22T16:20:07","modified_gmt":"2023-07-22T16:20:07","slug":"west-african-journal-of-pharmacy-2020-31-1-25-34","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2020-31-1-25-34\/","title":{"rendered":"West African Journal of Pharmacy (2020) 31 (1) 25 – 34"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

Ethanol extract of Celery (Apium graviolense) dissolved bilirubin gallstones in vitro<\/b><\/p>

\u00a0<\/b><\/p>

Olusegun S. Ajala and Oluwatobiloba Fajolu<\/p>

\u00a0<\/p>

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, CMUL Campus,\u00a0PMB 12003, Idiaraba, Surulere-Lagos, Nigeria<\/span><\/p>

Correspondence author: Olusegun S. Ajala<\/p>

Email:olusegunajala@yahoo.co.uk; Phone: +234 (0)8035622151<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t

ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

Background:<\/b> Oral litholysis is the medical alternative to the surgical treatment of cholelithiasis. While it is modestly\u00a0effective against the cholesterol type, it is completely of no effect against the bilirubin (or pigment) type. Whole\u00a0<\/span>celery plant is used in ethnomedicine for gallstone-related diseases and could be a source of new gallstone\u00a0<\/span>dissolving agents with possible bilirubin stone-dissolving capabilities.<\/span><\/p>

Objectives:<\/b> This work was aimed at investigating the potential dissolution capacity of an ethanol extract of whole\u00a0celery plant on bilirubin gallstones in vitro.<\/span><\/p>

Methods:<\/b> Gallstones obtained from a female sickle cell patient were collected from the department of surgery,\u00a0Lagos University Teaching Hospital (LUTH) Lagos, Nigeria, and confirmed bilirubin gallstones by morphological and\u00a0<\/span>UV spectrophotometric analyses. The dissolution capacity of an ethanol extract of celery on the gallstones was\u00a0<\/span>evaluated in vitro by stirring three separate Pre-weighed gall stones in 1 % w\/v aqueous solution of the crude\u00a0<\/span>extract over 72 hours, checking the gall stones for weight reduction every 10 minutes for 2 hours; hourly up to 5\u00a0<\/span>hours and then 24 hourly from 24 to 72 hours. Average weight reduction % was calculated at each point of\u00a0<\/span>measurement and compared, using t-test, with that of the control experiment in which an equal volume of distilled\u00a0<\/span>water was used in place of the extract suspension.<\/span><\/p>

Results:<\/b> The ethanol celery extract was found to cause a weight reduction % that was significantly higher than that\u00a0of the negative control at each point of measurement, p < 0.001.<\/span><\/p>

Conclusion:<\/b> This experiment has shown that ethanol extract of celery has bilirubin gallstone dissolving capacity\u00a0and could therefore be further explored for the discovery of new gallstone dissolving agents with possible bilirubin\u00a0<\/span>gallstone-dissolving capacity.<\/span><\/p>

Keywords:<\/b> Gallstone disease, Bilirubin cholelithiasis, Celery, Gallstone Oral litholysis<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Ethanol extract of Celery (Apium graviolense) dissolved bilirubin gallstones in vitro \u00a0 Olusegun S. Ajala and Oluwatobiloba Fajolu \u00a0 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos, CMUL Campus,\u00a0PMB 12003, Idiaraba, Surulere-Lagos, Nigeria Correspondence author: Olusegun S. Ajala Email:olusegunajala@yahoo.co.uk; Phone: +234 (0)8035622151 ABSTRACT Background: Oral litholysis is the medical alternative to the surgical […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[210],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4215"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4215"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4215\/revisions"}],"predecessor-version":[{"id":4221,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4215\/revisions\/4221"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4215"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4215"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}