{"id":4283,"date":"2023-07-10T13:49:11","date_gmt":"2023-07-10T13:49:11","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4283"},"modified":"2023-07-25T13:53:58","modified_gmt":"2023-07-25T13:53:58","slug":"west-african-journal-of-pharmacy-2020-31-1-119-128","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2020-31-1-119-128\/","title":{"rendered":"West African Journal of Pharmacy (2020) 31 (1) 119 – 128"},"content":{"rendered":"\t\t
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TLC and IR detection of sildenafil as an undeclared adulterant in some herbal\u00a0aphrodisiac products marketed in northwest Nigeria<\/span><\/b><\/p>

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Aminu T. Lawal , Aminu Musa , Musa A. Usman<\/p>

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1Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria.<\/span><\/p>

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Corresponding author: Aminu T. Lawal<\/p>

Email: lawalaminu463@gmail.com; Phone: +2347035860436<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Sildenafil, a phosphodiestrate-5 (PDE-5) inhibitor is used in the treatment of erectile dysfunction. There have been reports of adulteration of herbal products with PDE-5 inhibitors without considering its <\/span>deleterious consequences to public safety.<\/span><\/p>\n

Objectives:<\/b> To evaluate the presence of sildenafil as an undeclared adulterant in herbal products marketed in northwest Nigeria by TLC\/IR Spectroscopy.<\/span><\/p>\n

Methods:<\/b> A survey of herbal aphrodisiac products marketed in four Northwestern Nigerian states was carried out. A sample size (50) representative of the total products surveyed was collected for this study. A simple, rapid <\/span>thin layer chromatographic (TLC) method was employed for the identification of sildenafil adulterant in herbal <\/span>aphrodisiac samples. Presence of sildenafil from the suspected products was confirmed by Fourier transform <\/span>Infrared (FTIR) analysis.<\/span><\/p>\n

Results:<\/b> TLC method revealed 16 out of 50 herbal aphrodisiac samples to contain sildenafil which was affirmed by Infrared spectroscopy.<\/span><\/p>\n

Conclusion: <\/b>About 32% of the market products sampled were adulterated with sildenafil. The use of such products poses a serious threat to public safety.<\/span><\/p>\n

Keywords:<\/b> Herbal aphrodisiacs, sildenafil, adulteration, TLC, FTIR.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

TLC and IR detection of sildenafil as an undeclared adulterant in some herbal\u00a0aphrodisiac products marketed in northwest Nigeria \u00a0 Aminu T. Lawal , Aminu Musa , Musa A. Usman \u00a0 1Department of Pharmaceutical and Medicinal Chemistry, Ahmadu Bello University, Zaria, Nigeria. \u00a0 Corresponding author: Aminu T. Lawal Email: lawalaminu463@gmail.com; Phone: +2347035860436 ABSTRACT Background: Sildenafil, a […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[210],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4283"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4283"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4283\/revisions"}],"predecessor-version":[{"id":4289,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4283\/revisions\/4289"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4283"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4283"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4283"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}