{"id":4290,"date":"2023-07-09T13:54:57","date_gmt":"2023-07-09T13:54:57","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4290"},"modified":"2023-07-25T14:00:38","modified_gmt":"2023-07-25T14:00:38","slug":"west-african-journal-of-pharmacy-2020-31-1-129-142","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2020-31-1-129-142\/","title":{"rendered":"West African Journal of Pharmacy (2020) 31 (1) 129 – 142"},"content":{"rendered":"\t\t
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Formulation and evaluation of oral dissolving films of naproxen sodium from Terminalia randii gum<\/b><\/p>


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Oluyemisi A. Bamiro, Lateef G. Bakre, Olutayo A. Adeleye, Caroline O. Babalola, Mbang N. Femi-Oyewo<\/p>

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University,<\/p>

Sagamu, Nigeria<\/p>


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Corresponding author: Bamiro A. Oluyemisi<\/p>

Email: bamroy67@yahoo.co.uk; Phone: +2348023236963<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Oral films are gaining popularity and acceptance as new drug delivery systems, because of ease of administration and better patient compliance. However, most raw materials used in developing countries are <\/span>imported and expensive. Therefore, there is need to develop local and naturally occurring raw materials as <\/span>excipients.<\/span><\/p>\n

Objective:<\/b> This study evaluated the properties of naproxen sodium films prepared from a natural biodegradable polymer and the effect of formulation variables on the film properties.<\/span><\/p>\n

Method:<\/b> Naproxen films were produced by solvent casting method using hydroxypropyl methylcellulose and Terminalia randii gum as individual polymer and different combination ratios (1:1, 1:2 and 3:0). Ofada and corn <\/span>starches were used as disintegrants and glycerol as plasticizer. The films were assessed for thickness, weight <\/span>uniformity, surface pH, drug content, fold endurance and release properties. Compatibility of polymer, drug and <\/span>excipients was assessed using Fourier Transform Infra-Red.<\/span><\/p>\n

Results: <\/b>There was thickness uniformity with surface pH ranging between 5.8 and 6.8. The fold endurance was >300 for all formulations except in absence of plasticizer and presence ofTerminalia gum. There was significant (p<0.05) <\/span>weight variation of the films. Disintegration time ranking was no starch < corn starch <ofada starch. Films with <\/span>plasticizer had lower disintegration time. Drug released ranking was 1:1>1:2>3:0. Fourier Transform Infra-Red <\/span>showed that polymer-drug-excipient were compatible.<\/span><\/p>\n

Conclusion:<\/b> Terminalia randii gum has potential in naproxen oral disintegrating films formulation when combined with hydroxypropyl methylcellulose in particular ratios.<\/span><\/p>\n

Keywords:<\/b> Oral disintegrating film, Terminalia randii gum, Naproxen, Polymer<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Formulation and evaluation of oral dissolving films of naproxen sodium from Terminalia randii gum Oluyemisi A. Bamiro, Lateef G. Bakre, Olutayo A. Adeleye, Caroline O. Babalola, Mbang N. Femi-Oyewo Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Olabisi Onabanjo University, Sagamu, Nigeria Corresponding author: Bamiro A. Oluyemisi Email: bamroy67@yahoo.co.uk; Phone: +2348023236963 ABSTRACT Background: Oral […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[210],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4290"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4290"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4290\/revisions"}],"predecessor-version":[{"id":4296,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4290\/revisions\/4296"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4290"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4290"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4290"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}