{"id":4297,"date":"2023-07-08T14:01:06","date_gmt":"2023-07-08T14:01:06","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4297"},"modified":"2023-07-25T14:08:54","modified_gmt":"2023-07-25T14:08:54","slug":"west-african-journal-of-pharmacy-2020-31-1-143-154","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2020-31-1-143-154\/","title":{"rendered":"West African Journal of Pharmacy (2020) 31 (1) 143 – 154"},"content":{"rendered":"\t\t
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Quality assessment of fifteen brands of artemether-lumefantrine tablets in Lagos metropolis, Nigeria<\/b><\/p>

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Kehinde S. Salako, Aderonke A. Adepoju-Bello, Boladale O. Silva<\/p>

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1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of\u00a0<\/span>Lagos.\u00a0<\/span><\/p>

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2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos<\/span><\/p>

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Corresponding author: Kehinde S. Salako<\/p>

E-mail address: kobaweya@gmail.com; Phone no: +2348023461436<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Nigeria has been shown to have the highest number of malaria casualties worldwide. Due to the increased demand for anti-malarial drugs, the Nigerian pharmaceutical market is flooded with a wide range of <\/span>generic drugs whose quality must be regularly checked.<\/span><\/p>

Objectives:<\/b> The objective of this research was to carry out quality assessment of artemether-lumefantrine tablets marketed in Lagos metropolis, Nigeria.<\/span><\/p>

Methods:<\/b> Fifteen different brands of artemether-lumefantrine tablets gotten from five local government areas (Mushin, Oshodi-Isolo, Surulere, Ikorodu and Lagos Island) in Lagos were evaluated for weight variation, <\/span>diameter, thickness, disintegration, hardness, friability according to the methods specified in the British <\/span>Pharmacopoeia (2014) and the United States Pharmacopoeia (2014). The quantitative assay was carried out <\/span>according to a previous research by Vinodh et al., (2013) with some modifications.<\/span><\/p>

Results:<\/b> The results showed that 100 % of the tested brands of artemether-lumefantrine tablets passed the weight variation test, disintegration test (30 minutes) and diameter test (\u00b15% and \u00b13%,\u226412.5mm and >12.5 mm <\/span>respectively). It was observed that 87 % of the brands tested passed the friability test (\u22641%) and thickness test <\/span>(\u00b15% deviation) while 80 % conformed to the standard limit (4\u2013 10kp) for hardness. Only, 67% of the brands <\/span>tested conformed to the quantitative assay standard limit (90- 110%). Summarily, the results indicated that only <\/span>47 % of all the brands which included the innovator brand, passed all the tests carried out on them.<\/span><\/p>

Conclusion:<\/b> This study has been able to show that of all the brands of artemether-lumefantrine tablets assessed, 53% of the brands did not pass all the quality tests that they were subjected to. Hence, the importance of <\/span>continuous monitoring of the safety and efficacy of drugs.<\/span><\/p>

Keywords:<\/b> Artemether, Lumefantrine, Malaria, Pharmaceutical, quality<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Quality assessment of fifteen brands of artemether-lumefantrine tablets in Lagos metropolis, Nigeria \u00a0 Kehinde S. Salako, Aderonke A. Adepoju-Bello, Boladale O. Silva \u00a0 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of\u00a0Lagos.\u00a0 \u00a0 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos \u00a0 Corresponding author: Kehinde S. Salako E-mail address: kobaweya@gmail.com; Phone […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[210],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4297"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4297"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4297\/revisions"}],"predecessor-version":[{"id":4303,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4297\/revisions\/4303"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4297"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4297"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4297"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}