{"id":4311,"date":"2023-07-06T14:15:00","date_gmt":"2023-07-06T14:15:00","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4311"},"modified":"2023-07-25T14:22:25","modified_gmt":"2023-07-25T14:22:25","slug":"west-african-journal-of-pharmacy-2020-31-1-163-174","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2020-31-1-163-174\/","title":{"rendered":"West African Journal of Pharmacy (2020) 31 (1) 163 – 174"},"content":{"rendered":"\t\t
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Solid self-emulsifying drug delivery system for artemether with improved physicochemical properties: design and\u00a0<\/b>characterization.<\/b><\/p>

\u00a0<\/b><\/p>

Zwanden S. Yahaya , Avosuahi R. Oyi , Teryila S. Allagh , Abdulrahman Abdulsamad

<\/p>

1Department of Pharmaceutics and Industrial Pharmacy, Kaduna State University, Kaduna, Nigeria.<\/span><\/p>

2Department of Pharmaceutics and Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, Nigeria.<\/span><\/p>

\u00a0<\/p>

Corresponding author: Zwanden S. Yahaya<\/p>

Email: pharmzwanzy@gmail.com; Phone: +234 8060235790<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> The oral delivery of hydrophobic drugs presents a major challenge because of the low aqueous solubility of such compounds.<\/span><\/p>\n

Objectives:<\/b> The purpose of this study was to formulate artemether self-emulsifying drug delivery system (SEDDS) with natural oil from sesame seeds as one of the lipidic component, transform it into powder and evaluate its <\/span>potential in improving the release rate of artemether, a hydrophobic drug.<\/span><\/p>\n

Methods:<\/b> A self-emulsifying formulation of artemether composed of oil, surfactant, and co-surfactant was formulated and characterized with respect to globule size, polydispersity index (PDI), emulsification time, <\/span>ingredients compatibility and stability. The formulation was converted to powder by adsorption on Aerosil, <\/span>evaluated for flow and surface morphology using a scanning electron microscope. The formulation in vitro drug <\/span>release was determined and compared with a marketed product.<\/span><\/p>\n

Results: <\/b>The formulation was stable, showed excellent emulsification time of 6.0 s, had a mean globule size of \u00ae w <\/span>33.59 nm and PDI of 0.182. Direct incorporation of artemether-SEDDS into Aerosil at a ratio of 2:1 \/ (artemether- w <\/span>\u00ae <\/span>SEDDS: Aerosil ) resulted in a dry powder with good flow according to the Carr’s scale, with a mean particle size of <\/span>268.33\u03bcm, which were mostly spherical, with highly rough and porous surfaces. At 30 min, the marketed <\/span>formulation released 46 % drug lower than the solidify artemether-SEDDS<\/span><\/p>\n

Conclusion<\/b>: The study substantiates the usefulness of SEDDS for overcoming some of the physicochemical challenges associated with the delivery of artemether.<\/span><\/p>\n

Keywords:<\/b> artemether, antimalarial, globule size, solubility, sesame oil, formulation<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Solid self-emulsifying drug delivery system for artemether with improved physicochemical properties: design and\u00a0characterization. \u00a0 Zwanden S. Yahaya , Avosuahi R. Oyi , Teryila S. Allagh , Abdulrahman Abdulsamad 1Department of Pharmaceutics and Industrial Pharmacy, Kaduna State University, Kaduna, Nigeria. 2Department of Pharmaceutics and Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, Nigeria. \u00a0 Corresponding author: Zwanden S. […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[210],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4311"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4311"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4311\/revisions"}],"predecessor-version":[{"id":4317,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4311\/revisions\/4317"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4311"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4311"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4311"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}