{"id":4380,"date":"2023-07-26T16:04:45","date_gmt":"2023-07-26T16:04:45","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4380"},"modified":"2023-07-28T11:25:16","modified_gmt":"2023-07-28T11:25:16","slug":"http-wapcpharm-org-journal-wp-content-uploads-2023-07-chapter-8-2-pdf","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/http-wapcpharm-org-journal-wp-content-uploads-2023-07-chapter-8-2-pdf\/","title":{"rendered":"http:\/\/wapcpharm.org\/journal\/wp-content\/uploads\/2023\/07\/Chapter-8-2.pdf"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

Antiplasmodial activity of Rutidea smithii leaf extract and fractions of Hiern (Rubiaceae)<\/strong><\/p>

Sunday A. Adesegun , Nnaemeka Iwunze , Celestina I. Orabueze , Duncan Ota , Herbert A. B. Coker .<\/em>
Department of Pharmacognosy and Department of Pharmaceutical Chemistry, Faculty of Pharmacy,
Department of Physiology, College of Medicine, University of Lagos.<\/p>

Correspondence:<\/strong> Sunday Adesegun<\/em>
E-mail:\u00a0<\/strong>sadesegun@unilag.edu.ng<\/i>\u00a0<\/b>Phone:<\/strong> +2348035995080<\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t

ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

Background:<\/strong> Resistance to malaria infection has been of great public health concern all over the world especially in developing countries thus there is need for development of new antimalarial drugs. Natural products including medicinal plants are veritable sources for drug discovery hence their investigation for\u00a0possible antimalarial effects. Rutidea smithii is a woody climbing plant used traditionally in the treatment of headaches, colds and fevers.<\/p>

Objective:<\/b> To investigate the in vivo antimalarial activity of ethanol leaf extract and fractions of Rutidea smithii\u00a0in chloroquine-sensitive Plasmodium berghei-infected mice.
Methods: Swiss albino mice were intraperitoneally infected with chloroquine sensitive P. berghei (ANKA\u00a0strain). The mice were treated orally using suppressive and curative models with graded doses of extract of R.\u00a0smithii (100, 200 and 400 mg\/kg), fractions (50, 100 and 200 mg\/kg) and standard antimalarial drug;\u00a0chloroquine (10 mg\/kg). Preliminary phytochemical screening and acute toxicity study were also carried out.<\/p>

Results:<\/b> In the suppressive and curative tests, the extract demonstrated significant dose reduction in parasite\u00a0level (p < 0.05) in infected mice and the survival time was also prolonged. The antimalarial activity of the\u00a0fractions increased in the order hexane < butanol < aqueous < ethylacetate. The extract was devoid of toxicity\u00a0up to the highest dose tested (2000 mg\/kg).
Conclusion: Rutidea smithii has potent in vivo antiplasmodial activity against P. berghei which resides mainly in ethylacetate fraction thus is a veritable source of new antimalarial agents.<\/p>

Keywords:<\/strong> Rutidea smithii; Antimalarial; Curative; Suppressive; Ethylacetate fraction<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Antiplasmodial activity of Rutidea smithii leaf extract and fractions of Hiern (Rubiaceae) Sunday A. Adesegun , Nnaemeka Iwunze , Celestina I. Orabueze , Duncan Ota , Herbert A. B. Coker . Department of Pharmacognosy and Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Department of Physiology, College of Medicine, University of Lagos. Correspondence: Sunday Adesegun E-mail: sadesegun@unilag.edu.ng Phone: […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4380"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4380"}],"version-history":[{"count":5,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4380\/revisions"}],"predecessor-version":[{"id":4550,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4380\/revisions\/4550"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4380"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4380"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4380"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}