{"id":4405,"date":"2023-07-16T16:28:19","date_gmt":"2023-07-16T16:28:19","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4405"},"modified":"2023-07-27T13:51:33","modified_gmt":"2023-07-27T13:51:33","slug":"west-african-journal-of-pharmacy-2019-30-1-134-142-2","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2019-30-1-134-142-2\/","title":{"rendered":"West African Journal of Pharmacy (2019) 30 (1) 134 – 142"},"content":{"rendered":"\t\t
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Antioxidant activity, total phenolic and flavonoid contents of Anthocleista djalonensis root extracts<\/strong>

Patrick O. Igbinaduwa , Benjamin U. Okeke<\/em>

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria.<\/p>

Correspondence author:<\/strong> Patrick .O. Igbinaduwa<\/em>
Email:<\/strong> patrick.igbinaduwa@uniben.edu<\/em> Phone:<\/strong> +2347063806665<\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Anthocleista djalonensis (Chev.), a plant native to tropical West Africa, is used ethnomedicinally in the management of several diseases.<\/p>

Objectives:<\/b> This study seeks to determine the free radical scavenging ability of the methanol, ethyl acetate\u00a0and aqueous root extracts of A. djalonensis on 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and hydrogen peroxide
radicals and to determine the total phenolic and flavonoid contents of the extracts.<\/p>

Method:<\/b> The antioxidant effect of A. djalonensis root extracts was compared with that of ascorbic acid using\u00a0DPPH (2, 2- diphenyl-2- picrylhydrazyl) assay and hydrogen peroxide scavenging assay methods. Percentage\u00a0antioxidant activity (AA %), IC , total phenolic content and total flavonoid of extracts were determined. 50
Result: The total phenolic content of the extracts ranges from 132.73 \u00b1 20.25 to 207.93 \u00b1 11.7 mgGAE\/g of\u00a0dry plant extract while the total flavonoid content of the extracts ranges from 78.2 \u00b1 0.12 to 100.6 \u00b1 2.08 mg\u00a0QE\/g dry plant extract. The extracts showed a good but lower DPPH radical scavenging activity compared to
ascorbic acid. The methanol extract showed a maximum percentage radical scavenging of 94.76 \u00b1 0.05%\u00a0(IC = 148.54 \u00b5\/ml) on DPPH radicals at concentration of 1000 \u00b5g\/ml among the three extracts. The extracts 50\u00a0showed a non-significant (P \u02c3 0.05) radical scavenging activity on hydrogen peroxide compared to ascorbic
acid (74.14 \u00b1 0.05 %). The methanol extract have the highest hydrogen peroxide scavenging activity (79.24 \u00b1\u00a00.07 %).<\/p>

Conclusion:<\/b> This result indicates that the root extracts of Anthocleista djalonensis possess antioxidant phytochemicals and can be a good source of antioxidants to ameliorate conditions that are caused by the oxidative effects of free radicals.<\/p>

Key words:<\/b> Anthocleista djalonensis, DPPH, free radicals, oxidative stress<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Antioxidant activity, total phenolic and flavonoid contents of Anthocleista djalonensis root extracts Patrick O. Igbinaduwa , Benjamin U. Okeke Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria. Correspondence author: Patrick .O. IgbinaduwaEmail: patrick.igbinaduwa@uniben.edu Phone: +2347063806665 ABSTRACT Background: Anthocleista djalonensis (Chev.), a plant native to tropical West Africa, is used ethnomedicinally […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[211],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4405"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4405"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4405\/revisions"}],"predecessor-version":[{"id":4410,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4405\/revisions\/4410"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4405"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4405"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}