{"id":4411,"date":"2023-07-15T16:33:22","date_gmt":"2023-07-15T16:33:22","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4411"},"modified":"2023-07-28T11:34:42","modified_gmt":"2023-07-28T11:34:42","slug":"west-african-journal-of-pharmacy-2019-30-1-143-150-2","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2019-30-1-143-150-2\/","title":{"rendered":"West African Journal of Pharmacy (2019) 30 (1) 143 – 150"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

Investigation of antibacterial activities of Chrysophyllum albidum <\/strong>
cotyledon and its topical cream formulation<\/strong>

Stella Usifoh , Upe Babaiwa Florence Eichie , Joy Agbonkonkon<\/em>
Department of Clinical Pharmacy and Pharmacy Practice, Department of Pharmaceutical Microbiology,

Department of Pharmaceutics and Pharmaceutical Technology, University of Benin, Benin City, Nigeria<\/p>

\u00a0<\/p>

Corresponding author:<\/strong> Stella. Usifoh<\/em>
Email:<\/strong> sfusifoh@uniben.edu<\/em>; Phone:<\/strong> +234-8056226668<\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t

ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

Background:<\/strong> The emergence of multi-drug resistant bacteria has rekindled interest on plant-derived compounds as\u00a0substitutes for synthetically produced antibacterial agents.<\/p>

Objective:<\/b> This study determined the chemical constituent of Chrysophyllum albidum seeds, the antibacterial\u00a0activity of the ethanol extract and its topical cream formulation.<\/p>

Method:<\/strong> The antimicrobial activity of the seed extract was evaluated against S. aureus, E. coli, P. aeruginosa\u00a0and Klebsiella using agar diffusion method. Chemical constituents were determined with GC-MS.<\/p>

Results: <\/b>A solid, pleasant smelling and reddish brown coloured extract with a yield of 1.4%w\/v was obtained.
The extract inhibited growth of all test bacteria with an inhibitory zone diameter(IZD) of 20.3-22,5mm, while\u00a0the cream had IZD between 12.5-15mm. GC-MS profile of extract showed the presence of Oleic acid 32.0%,\u00a0Stearic acid19.86% and Palmitic acid 12.46% among other constituents which amounted to 35.68% of the\u00a0extract.<\/p>

Conclusion:<\/strong> The ethanolic extract of C. albidum seeds had antibacterial effects against gram-positive and gram-negative\u00a0bacteria. 14 chemical compounds including fatty acids; Oleic, Stearic and Palmitic acids have been
identified in the seeds. Formulation of extract into cream decreased antibacterial activity, suggestive of the
need to increase its concentration in the cream in order to achieve a favorable therapeutic effect.<\/p>

Keywords:<\/strong> Chrysophyllum albidum, anti-bacterial activities, gentamicin, topical cream, zone of inhibition.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Investigation of antibacterial activities of Chrysophyllum albidum cotyledon and its topical cream formulation Stella Usifoh , Upe Babaiwa Florence Eichie , Joy Agbonkonkon Department of Clinical Pharmacy and Pharmacy Practice, Department of Pharmaceutical Microbiology, Department of Pharmaceutics and Pharmaceutical Technology, University of Benin, Benin City, Nigeria Corresponding author: Stella. Usifoh Email: sfusifoh@uniben.edu; Phone: +234-8056226668 ABSTRACT […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[211],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4411"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4411"}],"version-history":[{"count":5,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4411\/revisions"}],"predecessor-version":[{"id":4551,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4411\/revisions\/4551"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4411"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4411"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4411"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}