{"id":4423,"date":"2023-07-20T13:32:11","date_gmt":"2023-07-20T13:32:11","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4423"},"modified":"2023-07-27T13:36:53","modified_gmt":"2023-07-27T13:36:53","slug":"west-african-journal-of-pharmacy-2019-30-1-88-95-2","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2019-30-1-88-95-2\/","title":{"rendered":"West African Journal of Pharmacy (2019) 30 (1) 88 – 95"},"content":{"rendered":"\t\t
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Antiplasmodial activity of leaf extract and fractions of Hiern (Rubiaceae)<\/b><\/p>

Sunday A. Adesegun , Nnaemeka Iwunze , Celestina I. Orabueze , Duncan Ota , Herbert A. B. Coker .<\/b><\/p>

\u00a0<\/p>

Department of Pharmacognosy and Department of Pharmaceutical Chemistry, Faculty of Pharmacy,<\/p>

\u00a0<\/p>

Department of Physiology, College of Medicine, University of Lagos.<\/p>

\u00a0<\/p>

Correspondence: Sunday Adesegun<\/p>

E-mail: Phone: +2348035995080<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Resistance to malaria infection has been of great public health concern all over the world\u00a0especially in developing countries thus there is need for development of new antimalarial drugs. Natural\u00a0<\/span>products including medicinal plants are veritable sources for drug discovery hence their investigation for\u00a0<\/span>possible antimalarial effects. Rutidea smithii is a woody climbing plant used traditionally in treatment of\u00a0<\/span>headache, cold and fever.<\/span><\/p>

Objective:<\/b> To investigate the in vivo antimalarial activity of ethanol leaf extract and fractions of Rutidea smithii\u00a0in chloroquine sensitive Plasmodium berghei infected mice.<\/span><\/p>

Methods:<\/b> Swiss albino mice were intraperitoneally infected with chloroquine sensitive P. berghei (ANKA\u00a0strain). The mice were treated orally using suppressive and curative models with graded doses of extract of R.\u00a0<\/span>smithii (100, 200 and 400 mg\/kg), fractions (50, 100 and 200 mg\/kg) and standard antimalarial drug;\u00a0<\/span>chloroquine (10 mg\/kg). Preliminary phytochemical screening and acute toxicity study were also carried out.<\/span><\/p>

Results:<\/b> In the suppressive and curative tests, the extract demonstrated significant dose reduction in parasite\u00a0level (p < 0.05) in infected mice and the survival time was also prolonged. The antimalarial activity of the\u00a0<\/span>fractions increased in the order hexane < butanol < aqueous < ethylacetate. The extract was devoid of toxicity\u00a0<\/span>up to the highest dose tested (2000 mg\/kg).<\/span><\/p>

Conclusion:<\/b> Rutidea smithii has potent in vivo antiplasmodial activity against P. berghei which resides mainly in\u00a0ethylacetate fraction thus is a veritable source of new antimalarial agents.<\/span><\/p>

Keywords:<\/b> Rutidea smithii; Antimalarial; Curative; Suppressive; Ethylacetate fraction<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Antiplasmodial activity of leaf extract and fractions of Hiern (Rubiaceae) Sunday A. Adesegun , Nnaemeka Iwunze , Celestina I. Orabueze , Duncan Ota , Herbert A. B. Coker . \u00a0 Department of Pharmacognosy and Department of Pharmaceutical Chemistry, Faculty of Pharmacy, \u00a0 Department of Physiology, College of Medicine, University of Lagos. \u00a0 Correspondence: Sunday Adesegun […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[211],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4423"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4423"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4423\/revisions"}],"predecessor-version":[{"id":4429,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4423\/revisions\/4429"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}