{"id":4444,"date":"2023-07-24T14:38:16","date_gmt":"2023-07-24T14:38:16","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4444"},"modified":"2023-07-27T14:54:49","modified_gmt":"2023-07-27T14:54:49","slug":"west-african-journal-of-pharmacy-2017-28-1-23-34","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2017-28-1-23-34\/","title":{"rendered":"West African Journal of Pharmacy (2017) 28 (1) 23-34"},"content":{"rendered":"\t\t
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Garcinia kola prevents scopolamine-induced memory impairment in mice: Role of oxidative\u00a0<\/b>and nitrosative stress<\/b><\/p>

\u00a0<\/p>

Ismail O. Ishola , Wahab O. Okunowo , Gbenga O. Afolayan, Azeezat A. Awoyemi<\/p>

1Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences,\u00a0<\/span>College of Medicine, University of Lagos, PMB 12003, Idi-araba, Lagos, Nigeria.<\/span><\/p>

2Department of Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, University\u00a0<\/span>of Lagos, PMB 12003, Idi-araba, Lagos, Nigeria.<\/span><\/p>

\u00a0<\/span><\/p>

Corresponding author : Ismail Ishola<\/p>

Email add: oishola@cmul.edu.ng Phone : +2348033018908<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background: The high and increasing incidence of Alzheimer Disease (AD) worldwide is a major\u00a0global concern. Oxidative stress has been considered to be linked to the aetiology of many diseases,\u00a0<\/span>including neurodegenerative diseases (NDDs) such as AD. Garcinia kola Heckel (Clusiaceae) has\u00a0<\/span>important antioxidant functions that can help protect against AD.<\/span><\/p>

Objective:<\/b> This study sought to investigate the protective effect of ethanol seed extract of Garcinia\u00a0kola (GCK) on scopolamine-induced memory impairment in rodents.<\/span><\/p>

Methods:<\/b> GCK (25, 50 and 100 mg\/kg, p. o.) or tacrine (5 mg\/kg, i. p.) was administered for 3\u00a0consecutive days. Scopolamine (3 mg\/kg, i. p.) was given, 1 h after last-treatment on day 3, followed\u00a0<\/span>by estimation of memory functions using the Y-maze and elevated plus maze (EPM) tasks in mice as\u00a0<\/span>well as Morris water maze test (MWM) in rats. The biochemical markers of oxidative stress were\u00a0<\/span>determined in the prefrontal cortex, hippocampus and striatum after the MWM test on day 8.<\/span><\/p>

Results:<\/b> Scopolamine induced significant decrease in spontaneous alternation behaviour in Y-maze\u00a0and increased transfer latency in EPM in mice which was prevented by pretreatment of mice with\u00a0<\/span>GCK. In the MWM experiment, GCK protected rats against spatial learning deficit induced by\u00a0<\/span>scopolamine, evidenced in session dependent decrease in escape latency. Furthermore,\u00a0<\/span>scopolamine induced increased oxidative and nitrosative stress status in the prefrontal cortex,\u00a0<\/span>striatum and hippocampus as compared with vehicle-treated control was ameliorated with GCK\u00a0<\/span>administration which was similar to the effect of tacrine.<\/span><\/p>

Conclusion:<\/b> G. kola prevented scopolamine-induced cognitive impairment through attenuation of\u00a0oxidative\/nitrosative stress status. Thus, could be a potential phytotherapeutic agent in the\u00a0<\/span>treatment of dementia.<\/span><\/p>

Keywords:<\/b> Antioxidant system; hippocampus; Morris water maze; scopolamine; Y-maze<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Garcinia kola prevents scopolamine-induced memory impairment in mice: Role of oxidative\u00a0and nitrosative stress \u00a0 Ismail O. Ishola , Wahab O. Okunowo , Gbenga O. Afolayan, Azeezat A. Awoyemi 1Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences,\u00a0College of Medicine, University of Lagos, PMB 12003, Idi-araba, Lagos, Nigeria. 2Department of Biochemistry, Faculty of Basic […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[230],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4444"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4444"}],"version-history":[{"count":8,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4444\/revisions"}],"predecessor-version":[{"id":4455,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4444\/revisions\/4455"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4444"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4444"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4444"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}