{"id":4469,"date":"2023-07-21T15:30:04","date_gmt":"2023-07-21T15:30:04","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4469"},"modified":"2023-07-27T15:37:06","modified_gmt":"2023-07-27T15:37:06","slug":"west-african-journal-of-pharmacy-2017-28-1-61-71","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2017-28-1-61-71\/","title":{"rendered":"West African Journal of Pharmacy (2017) 28 (1) 61-71"},"content":{"rendered":"\t\t
\n\t\t\t\t\t\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

A comparative evaluation of the pharmaceutical quality of different brands of metformin\u00a0<\/b>hydrochloride tablets available in Abuja, Nigeria<\/b><\/p>

\u00a0<\/b><\/p>

Sylvester O. Eraga, Matthew I. Arhewoh, Enifome P. Oruh and Magnus A. Iwuagwu<\/p>

\u00a0<\/p>

Department of Pharmaceutics and Pharmaceutical Technology,<\/p>

Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, 300001, Nigeria.<\/p>

\u00a0<\/p>

Corresponding author: Sylvester Eraga<\/p>

E-mail: eragaso@uniben.edu, Tel: +2348030884928<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t

ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
\n\t\t\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t
\n\t\t\t\t\t\t\t\t
\n\t\t\t\t
\n\t\t\t\t\t\t\t

Background:<\/b> Metformin hydrochloride tablets are the most commonly prescribed drug for the management of\u00a0Type II Diabetes Mellitus. This has resulted in increased importation and manufacturing of various brands of\u00a0<\/span>the tablets in Nigeria.<\/span><\/p>

Objective:<\/b> To evaluate the pharmaceutical quality of different brands of metformin hydrochloride tablets\u00a0available in Abuja, Nigeria.<\/span><\/p>

Method:<\/b> Ten brands of metformin hydrochloride tablets were purchased and subjected to pharmaceutical\u00a0quality evaluations such as friability, hardness, disintegration and dissolution tests. Content of active\u00a0<\/span>pharmaceutical ingredient (API) was determined using spectrophotometric analysis as well as reverse phase-<\/span>high performance liquid chromatography (RP-HPLC).<\/span><\/p>

Results:<\/b> All the brands were elegantly labelled, packaged and within their shelf lives. With exception of one\u00a0brand, they all had NAFDAC registration number. The weight uniformity, friability, hardness and disintegration\u00a0<\/span>time values for all the brands were within acceptable limits. Three brands of the products released less than 70<\/span>% of their API after 45 min and therefore failed the dissolution test. There was disparity between content assay\u00a0<\/span>results using UV spectrophotometry and HPLC. HPLC results showed that only brand failed the test by having 86<\/span>% of the API while with UV spectrophotometry; four brands failed the test.<\/span><\/p>

Conclusion:<\/b> This investigation suggest that four brands of metformin hydrochloride tablets available in Abuja,\u00a0did not met official specifications even though only one brand was implicated by HPLC analysis. Consequently,\u00a0<\/span>this research would recommend continuous sentinel surveillance of metformin tablets and the use of HPLC for\u00a0<\/span>product analysis for its high sensitivity and accuracy.<\/span><\/p>

Keywords:<\/b> Metformin, UV, RP-HPLC, assay, pharmaceutical quality, label claim<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t
\n\t\t\t\t\t
\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

A comparative evaluation of the pharmaceutical quality of different brands of metformin\u00a0hydrochloride tablets available in Abuja, Nigeria \u00a0 Sylvester O. Eraga, Matthew I. Arhewoh, Enifome P. Oruh and Magnus A. Iwuagwu \u00a0 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, PMB 1154, Benin City, 300001, Nigeria. \u00a0 Corresponding author: Sylvester Eraga […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[230],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4469"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4469"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4469\/revisions"}],"predecessor-version":[{"id":4475,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4469\/revisions\/4475"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4469"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4469"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4469"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}