{"id":4576,"date":"2023-07-27T13:06:45","date_gmt":"2023-07-27T13:06:45","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4576"},"modified":"2023-07-28T13:12:09","modified_gmt":"2023-07-28T13:12:09","slug":"west-african-journal-of-pharmacy-2017-28-2-16-25-2","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2017-28-2-16-25-2\/","title":{"rendered":"West African Journal of Pharmacy (2017) 28 (2) 16-25"},"content":{"rendered":"\t\t
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Quality assessment of ten brands of ofloxacin tablets marketed in Lagos, Nigeria.<\/b><\/p>


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Aderonke Adepoju-Bello , Hannat Akanbi and Teddy Ehianeta<\/p>


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1Department of Pharmaceutical Chemistry, Faculty of Pharmacy,<\/span><\/p>

College of Medicine, University of Lagos,<\/p>

Idi-Araba Campus, P.M.B. 12003, Lagos, Nigeria.<\/p>


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Corresponding author: Aderonke Adepoju-Bello<\/p>

E-mail: adepojubello@yahoo.com Telephone: +2348025281213<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Ofloxacin is a synthetic chemotherapeutic agent used to treat severe and life threatening\u00a0infections. It is a fluoroquinolone antibiotic with broad spectrum of activity.<\/span><\/p>

Objectives:<\/b> This study is aimed at evaluating some physicochemical parameters and assay of ten different\u00a0brands of ofloxacin 200 mg tablets sourced from various pharmaceutical stores in Lagos.<\/span><\/p>

Methods:<\/b> The physicochemical tests carried out include uniformity of weight, hardness, friability,\u00a0disintegration and dissolution tests according to the BP and USP established methods. The quantitative assay\u00a0<\/span>was carried out using the UV\/visible spectrophotometry. Similarity factor (f ) was used to assess the 2\u00a0<\/span>dissolution profile among the brands.<\/span><\/p>

Results:<\/b> The results indicated that all brands complied with the official specification for uniformity of weight,\u00a0friability, and disintegration. However, the dissolution profiles in 0.1N HCl showed that only one brand (OFLO-<\/span>6) failed to attain 80% dissolution in 30 min, although it passed quantitative assay test. The quantitative assay\u00a0<\/span>showed that two brands (OFLO-2 and OFLO-7) contained less than 90% of labeled ofloxacin content. OFLO-6,\u00a0<\/span>OFLO-7 and OFLO-10 brands showed dissimilarity in dissolution profile relative to the innovator brand (OFLO-<\/span>1), thus may not be used interchangeably within clinical considerations.<\/span><\/p>

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Conclusion:<\/b> The result shows that chemical equivalence does not indicate bioequivalence. Owing to the vast\u00a0influx of pharmaceuticals into the Nigeria drug market, it is important that regulatory agencies engage in\u00a0<\/span>periodic post-marketing analytical quality assessment.<\/span><\/p>

Keywords<\/b>: Ofloxacin brands, post market quality assessment, similarity factor.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Quality assessment of ten brands of ofloxacin tablets marketed in Lagos, Nigeria. Aderonke Adepoju-Bello , Hannat Akanbi and Teddy Ehianeta 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, College of Medicine, University of Lagos, Idi-Araba Campus, P.M.B. 12003, Lagos, Nigeria. Corresponding author: Aderonke Adepoju-Bello E-mail: adepojubello@yahoo.com Telephone: +2348025281213 ABSTRACT Background: Ofloxacin is a synthetic chemotherapeutic agent […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[233],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4576"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4576"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4576\/revisions"}],"predecessor-version":[{"id":4582,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4576\/revisions\/4582"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4576"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4576"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4576"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}