{"id":4654,"date":"2023-07-16T15:12:58","date_gmt":"2023-07-16T15:12:58","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4654"},"modified":"2023-07-28T15:18:52","modified_gmt":"2023-07-28T15:18:52","slug":"west-african-journal-of-pharmacy-2017-28-2-143-149","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2017-28-2-143-149\/","title":{"rendered":"West African Journal of Pharmacy (2017) 28 (2) 143-149"},"content":{"rendered":"\t\t
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Short Communication<\/b><\/p>

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Effect of diclofenac and paracetamol on anticonvulsant activity of phenytoin and sodium\u00a0<\/b>valproate in laboratory animals<\/b><\/p>

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Jamilu Ya’u , Sani Malami , Abubakar Yakubu and Joseph A. Anuka<\/p>

1Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria<\/span><\/p>

2Department of Pharmacology and Therapeutics, Bayero University, Kano, Nigeria<\/span><\/p>

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Corresponding author: Jamilu Ya’u,<\/p>

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Email yjamilu@abu.edu.ng Phone +2348032415294<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Neuroinflammation is a major contributor to neurological and neurodegenerative diseases, and inflammatory processes have been implicated in both acute and chronic conditions such as epilepsy. <\/span>Cyclooxygenase (COX) inhibitors, are used largely to treat febrile condition, pain state and inflammation, <\/span>through their role in the inhibition of prostaglandin synthesis. Thus, drugs that reduce the production of <\/span>prostaglandins may have beneficial effect in epilepsy.<\/span><\/p>

Objective:<\/b> The present study is aimed at evaluating possible effects of diclofenac and paracetamol on the anticonvulsant outcome of phenytoin and sodium valproate in chicks and mice.<\/span><\/p>

Methods:<\/b> Electrically and chemically-induced seizure models, using maximal electroshock test (MEST) in chicks and pentylenetetrazole (PTZ) test in mice, respectively, were used for the study.<\/span><\/p>

Results:<\/b> Co-administration (i.p.) of diclofenac (20 mg\/kg) and paracetamol (100 mg\/kg), each with phenytoin (15 mg\/kg, i.p.), potentiated the anticonvulsant outcome of phenytoin in MEST. Diclofenac-phenytoin and <\/span>paracetamol-phenytoin administrations exhibited 90% and 80% protection, respectively, as against the 0% <\/span>protection produced when diclofenac and paracetamol were administered alone. Similarly, there was <\/span>statistical significant decrease (p<0.05) in the recovery time from seizures between the groups co-<\/span>administered with the two drugs and those that received individual drugs. In PTZ-induced seizure test, there <\/span>was slight decrease in seizure protection (60%); with significant increase (p<0.05) in the mean onset of <\/span>seizures when diclofenac (20 mg\/kg) and sodium valproate (100 mg\/kg) were co-administered; while <\/span>valproate (100 mg\/kg) exhibited 80% protection with no significant increase (p<0.05) in the mean onset of <\/span>seizures. Also, similar protection of 80% was obtained when paracetamol (100 mg\/kg) and valproate (100 <\/span>mg\/kg) were co-administered showing no potentiation or antagonism in PTZ-induced seizure test.<\/span><\/p>

Conclusion:<\/b> The results of this study showed potentiating effect when diclofenac and phenytoin; paracetamol and phenytoin, were co-administered. Therefore, the co-administration may be beneficial in <\/span>generalized tonic-clonic seizures.<\/span><\/p>

Key words<\/b>: Diclofenac; Paracetamol; Phenytoin; Valproate ; Cyclooxygenase<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Short Communication \u00a0 Effect of diclofenac and paracetamol on anticonvulsant activity of phenytoin and sodium\u00a0valproate in laboratory animals \u00a0 Jamilu Ya’u , Sani Malami , Abubakar Yakubu and Joseph A. Anuka 1Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria 2Department of Pharmacology and Therapeutics, Bayero University, Kano, Nigeria \u00a0 Corresponding author: Jamilu Ya’u, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[233],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4654"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4654"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4654\/revisions"}],"predecessor-version":[{"id":4660,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4654\/revisions\/4660"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4654"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4654"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4654"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}