{"id":4689,"date":"2023-07-31T12:10:06","date_gmt":"2023-07-31T12:10:06","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4689"},"modified":"2023-07-31T12:16:23","modified_gmt":"2023-07-31T12:16:23","slug":"west-african-journal-of-pharmacy-2016-27-2-1-15","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2016-27-2-1-15\/","title":{"rendered":"West African Journal of Pharmacy (2016) 27 (2) 1-15"},"content":{"rendered":"\t\t
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Formula Optimization of 100 mg Chewable Ascorbic Acid Tablets<\/b><\/p>

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Uduma E. Osonwa , Eugene C. Uzuegbunam , Kenneth Ugoeze , Kingsley I. Chukwu and Onyinye J Uwaezuoke<\/p>

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1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of<\/span><\/p>

Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria<\/p>

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2Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of\u00a0<\/span>Pharmacy, Houston, Texas, United States<\/span><\/p>

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3Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences,\u00a0<\/span>University of Port Harcourt, Port Harcourt, Nigeria<\/span><\/p>

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4.Department of Pharmaceutics, College of Pharmacy and Nutrition, University of Saskatchewan-Canada<\/span><\/p>

5.Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy,\u00a0Olabisi Onabanjo University, Ago-Iwoye, Ogun state, Nigeria.<\/span><\/p>

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Corresponding author: Uduma Osonwa<\/p>

Email: udumaosonwa@yahoo.com; Phone : +2348038733305<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Ascorbic acid is a water soluble nigh dose drug that usually degrades in the presence of moisture with the formation of not so biologically active substances.. Pharmaceutical excipients have long been used <\/span>to impart functionalities that improve stability and enhance patient compliance while increasing cost. <\/span>Optimization therefore aims at achieving a compromise between a given set of constraints that yields the <\/span>best formulation.<\/span><\/p>\n

Objectives:<\/b> The aim of this work is to produce optimised formulation of 100 mg chewable ascorbic acid tablet.<\/span><\/p>\n

Methods:<\/b> The lubricant was stearic acid at 0.25 %, 0.5% or 0.75 %. The direct compression excipient (DCE) used was Avicel\u00ae PH 102 with sorbitol as sweetener in the ratios of sorbitol to Avicel of 1:0, 0:1, 1:1 1:2, 1:3, 1:<\/span>4 respectively. The tablet weight was calculated such that the concentration of drug is 30-50% of the direct <\/span>compression excipient (DCE). A step-wise optimization approach was employed. The best batch was selected <\/span>as having the highest DCE dilution, hardness \u22654 kgf, minimal tablet defects, and acceptable weight variation, <\/span>content and content variation.<\/span><\/p>\n

Results:<\/b> The optimal formula was obtained with the batch that has the following formula, 0.75 % stearic acid at a maximum DCE ratio of avicel: sorbitol of 4 :1 at dilution of 40 % w\/w. The flow rate of the powder mix for <\/span>this batch was 29.70 g\/s, with Carrs compressibility index of 22%, and Hausner ratio of 1.28. The angle of <\/span>repose determined by free flow from a height of 4 cm was 23 . Drug-excipient compatibility studies using DSC <\/span>revealed no significant interaction between the tablet components except possible change in crystal <\/span>structure.<\/span><\/p>\n

Conclusion:<\/b> The optimal formulation had the following formula: 0.75 % stearic acid, 4 Avicel: 1 sorbitol, and at a maximum DCE dilution of 40% w\/w.<\/span><\/p>\n

Keywords:<\/b> Ascorbic acid; tablet; direct compression; sequential; optimal formula<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Formula Optimization of 100 mg Chewable Ascorbic Acid Tablets \u00a0 Uduma E. Osonwa , Eugene C. Uzuegbunam , Kenneth Ugoeze , Kingsley I. Chukwu and Onyinye J Uwaezuoke \u00a0 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka, Nigeria \u00a0 2Department of Pharmacological and Pharmaceutical Sciences, University of Houston College […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[225],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4689"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4689"}],"version-history":[{"count":7,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4689\/revisions"}],"predecessor-version":[{"id":4698,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4689\/revisions\/4698"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4689"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4689"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4689"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}