{"id":4734,"date":"2023-07-25T13:55:19","date_gmt":"2023-07-25T13:55:19","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4734"},"modified":"2023-07-31T13:59:52","modified_gmt":"2023-07-31T13:59:52","slug":"west-african-journal-of-pharmacy-2016-27-2-78-88","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2016-27-2-78-88\/","title":{"rendered":"West African Journal of Pharmacy (2016) 27 (2) 78-88"},"content":{"rendered":"\t\t
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Enhancement of the solubility, bioavailability and absorption of poorly soluble drug candidates\u00a0<\/b>through nanotechnology- a review.<\/b><\/p>

\u00a0<\/b><\/p>

Stephen Olaribigbe Majekodunmi<\/p>

\u00a0<\/p>

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy,\u00a0University of Uyo, P.M.B. 1017, Uyo, Nigeria.<\/span><\/p>

\u00a0<\/span><\/p>

Corresponding author: Stephen Olaribigbe Majekodunmi<\/p>

E-mail: stephenolari@uniuyo.edu.ng Phone: +234 809 0621 133<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background: <\/b>Orally administered drugs that transverse the intestinal membrane must be very soluble and lipophilic. This may not be so as most drugs are poorly soluble and thus possess poor bioavailability resulting <\/span>in only a small fraction of the administered drugs absorbed into the systemic circulation and reach the target <\/span>site. Thus, a major amount of the drug is wasted and the unabsorbed drug leads to undesired side effects in <\/span>the gastrointestinal tract.<\/span><\/p>\n

Objectives:<\/b> The objective is to review some of the various drug delivery technologies used to formulate poorly soluble drug candidates through nanotechnology.<\/span><\/p>\n

Methods:<\/b> Formulating these compounds as pure drug nanoparticles is one of the newer drug-delivery strategies applied to this class of molecules. Nanocrystals, a carrier-free colloidal delivery system in nano-<\/span>sized range, is an interesting approach for poorly soluble drugs. Several strategies are applied for nanocrystals <\/span>production including precipitation, milling, high pressure homogenization and combination methods such as <\/span>Nano- EdgeTM, SmartCrystal and Precipitation-lyophilization-homogenization (PLH) technology.<\/span><\/p>\n

Results:<\/b> Nanoparticle dispersions are stable and have a mean diameter of less than 1 micron. Drug nanoparticles have been shown to improve bioavailability and enhance drug exposure for oral and parenteral <\/span>dosage forms. Nanocrystals provide special features including enhancement of saturation solubility, <\/span>dissolution velocity and adhesiveness to surface\/cell membranes.<\/span><\/p>\n

Conclusions:<\/b> Many publications reported useful advantages of nanocrystals to improve in vivo performances such as pharmacokinetics, pharmacodynamics, safety and targeted delivery which are discussed in this <\/span>review.<\/span><\/p>\n

Keywords:<\/b> Nanoparticles, Nanocrystal Technology, Bioavailability, poorly water soluble compounds.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Enhancement of the solubility, bioavailability and absorption of poorly soluble drug candidates\u00a0through nanotechnology- a review. \u00a0 Stephen Olaribigbe Majekodunmi \u00a0 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy,\u00a0University of Uyo, P.M.B. 1017, Uyo, Nigeria. \u00a0 Corresponding author: Stephen Olaribigbe Majekodunmi E-mail: stephenolari@uniuyo.edu.ng Phone: +234 809 0621 133 ABSTRACT Background: Orally administered drugs that transverse […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[225],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4734"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4734"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4734\/revisions"}],"predecessor-version":[{"id":4740,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4734\/revisions\/4740"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4734"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4734"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}