{"id":4741,"date":"2023-07-23T14:00:21","date_gmt":"2023-07-23T14:00:21","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4741"},"modified":"2023-07-31T14:12:40","modified_gmt":"2023-07-31T14:12:40","slug":"west-african-journal-of-pharmacy-2016-27-2-89-101","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2016-27-2-89-101\/","title":{"rendered":"West African Journal of Pharmacy (2016) 27 (2) 89-101"},"content":{"rendered":"\t\t
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Formulation of antimicrobial cream from the leaves and bark of Lannea welwitschii for wound healing.<\/b><\/p>


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Omotunde Okubanjo, Uzoma Nonso-Sylver, Sunday Ojo and Magaret Ilomuanya<\/p>

1Department of Pharmaceutics and Pharmaceutical Technology,<\/span><\/p>

Faculty of Pharmacy University of Lagos, Lagos, Nigeria.<\/p>


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Correspondence author: Omotunde Okubanjo<\/p>

E-mail: mokubanjo@unilag.edu.ng; Phone: +234 – 803-714-7599<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Recently there has been a remarkable surge of interest in natural products and their applications in the cosmetic industry. Topical delivery of antimicrobials from natural sources like Lannea welwitschii is one of <\/span>the approaches used to treat wounds due to its diverse clinical and pharmacological potentials.<\/span><\/p>\n

Objectives:<\/b> The aim of this study was to develop an oil-in-water cream formulation of the methanol extract of the leaves (LF) and bark (BF) of Lannea welwitschii (Hiern) Engl. (Fam. Anacardiaceae) for topical delivery in the <\/span>treatment of wound infections.<\/span><\/p>\n

Methods:<\/b> The antimicrobial activity of the extract was investigated. The cream was formulated using fusion method. The oil-phase ingredients were slowly transferred into the aqueous phase at a temperature of 70 \u00b0C <\/span>including the extracts 1%w\/w with constant stirring. The formulations upon cooling were evaluated for pH, skin <\/span>irritancy, viscosity, colour and odour. The stability of the cream over 30 days was investigated so also the wound <\/span>healing properties of the cream was studied in 12 albino rats using the excision wound healing model.<\/span><\/p>\n

Results:<\/b> The minimum inhibitory concentration for both the leaf and bark extract was 4mg \/ml. The extracts were most active against Proteus mirabilis with the leaf extract being more active than the bark <\/span>extract. The extracts also had activity against Bacillus subtilis and Pseudomonas aeruginosa, with mean <\/span>inhibition zone diameter ranging from 10-26mm. There was no antifungal activity observed. The four resulting <\/span>cream formulations were homogenous, highly viscous, non-greasy, slightly acidic and non-irritant. The cream <\/span>formulations from the leaf and bark extract were green and red respectively. There was no significant change in <\/span>the evaluation parameters at 25 \u00b0C over a period of four weeks. The formulations appeared stable over the <\/span>period. Statistical analysis showed that after a twenty-one day treatment on an excised wound, the two <\/span>formulations showed comparable wound-healing with the standard (Cicatrin ). LF2 showed a significantly <\/span>higher rate of wound closure (P < 0.05) than Bf2.<\/span><\/p>\n

Conclusion:<\/b> A standardized cream formulation of the extract from the plant Lannea welwitschii for wound healing was developed. The cream was found to be aesthetically acceptable, stable, therapeutically effective, <\/span>and, hence has promising wound healing potentials in the health care industry.<\/span><\/p>\n

Keywords:<\/b> Lanneawelwitschii, methanol extract, wound-healing, antimicrobial cream formulation.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Formulation of antimicrobial cream from the leaves and bark of Lannea welwitschii for wound healing. Omotunde Okubanjo, Uzoma Nonso-Sylver, Sunday Ojo and Magaret Ilomuanya 1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy University of Lagos, Lagos, Nigeria. Correspondence author: Omotunde Okubanjo E-mail: mokubanjo@unilag.edu.ng; Phone: +234 – 803-714-7599 ABSTRACT Background: Recently there has been a […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[225],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4741"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4741"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4741\/revisions"}],"predecessor-version":[{"id":4747,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4741\/revisions\/4747"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}