{"id":4777,"date":"2023-07-30T14:39:12","date_gmt":"2023-07-30T14:39:12","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4777"},"modified":"2023-07-31T14:44:08","modified_gmt":"2023-07-31T14:44:08","slug":"west-african-journal-of-pharmacy-2016-27-1-22-32","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2016-27-1-22-32\/","title":{"rendered":"West African Journal of Pharmacy (2016) 27 (1) 22-32"},"content":{"rendered":"\t\t
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Antinociceptive and anti-inflammatory properties of hydroethanolic seed extract of Monodora\u00a0<\/b>myristica (Annonaceae) in rodents<\/b><\/p>

\u00a0<\/b><\/p>

I<\/b>smail O. Ishola, Victor O. Ikumawoyi, Gbenga O. Afolayan, Oshoname J. Olorife<\/p>

Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences,<\/p>

\u00a0<\/p>

College of Medicine, University of Lagos, PMB 12003, Lagos, Nigeria.<\/p>

\u00a0<\/p>

Corresponding author: Ismail O. Ishola<\/p>

Email: oishola@cmul.edu.ng Phone: +2348033018908<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Monodora myristica (Gaertn) Dunal (Annonaceae) is used in traditional medicine for cough, rheumatism, hemorrhoids, diabetes, anemia and headaches.<\/span><\/p>\n

Objective:<\/b> This study was carried out to investigate the antinociceptive and anti-inflammatory effects of the hydroethanolic seeds extract of Monodora myristca (HMM) in rodents.<\/span><\/p>\n

Methods:<\/b> HMM (50-200 mg\/kg, p.o.) was administered 1 h before intraperitoneal or intraplantar injection of V <\/span>0.6% \/v acetic acid or 1% formalin (20 \u03bcL), respectively, to evaluate the antinociceptive property. Acute and<\/span>chronic anti-inflammatory effect was investigated using carrageenan-induced paw and xylene-induced ear <\/span>oedema, and cotton-pellet induced granuloma tests, respectively.<\/span><\/p>\n

Results:<\/b> HMM (50-200 mg\/kg) produced dose dependent and significant decrease in mean number of writhes in acetic acid-induced nociception and increased pain threshold to neurogenic and inflammatory <\/span>pain with 48.59 and 34.2% inhibition, respectively, in the formalin-induced nociception assay. The HMM-<\/span>induced antinociception was completely blocked by pre-treatment of mice with naloxone, p-<\/span>Chlorophenyalanine (serotonin synthase inhibitor; 100 mg\/kg, i.p.) and sulpiride (D receptor antagonist; 2<\/span>50mg\/kg) whereas glibenclamide (K sensitive channels blocker; 10 mg\/kg) failed to reverse the ATP <\/span>antinociceptive effect of the extract. In acute inflammatory model, HMM produced time course inhibition of <\/span>carrageenan-induced paw oedema. In addition, pretreatment of mice with HMM inhibited xylene-induced <\/span>ear oedema by 60% comparatively similar to the effect of dexamethasone (83.90%). Moreover, in the cotton-<\/span>pellet granuloma pouch, HMM (200 mg\/kg) reduced granuloma formation by 52%.<\/span><\/p>\n

Conclusion:<\/b> The hydro-ethanolic seed extract of M. myristica possesses antinociceptive effect mediated <\/span>through interaction with opioidergic, serotonergic and dopaminergic systems and an anti-inflammatory <\/span>action through inhibition of inflammatory mediator’s release. Finally, the study established the scientific basis <\/span>for its use in the management of pain and inflammatory conditions in traditional medicine.<\/span><\/p>\n

Keywords:<\/b> Anti-nociceptive, anti-inflammatory, opioid, serotonergic, dopaminergic, Monodora myristica<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Antinociceptive and anti-inflammatory properties of hydroethanolic seed extract of Monodora\u00a0myristica (Annonaceae) in rodents \u00a0 Ismail O. Ishola, Victor O. Ikumawoyi, Gbenga O. Afolayan, Oshoname J. Olorife Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences, \u00a0 College of Medicine, University of Lagos, PMB 12003, Lagos, Nigeria. \u00a0 Corresponding author: Ismail O. Ishola Email: […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[226],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4777"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4777"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4777\/revisions"}],"predecessor-version":[{"id":4783,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4777\/revisions\/4783"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4777"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4777"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4777"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}