{"id":4784,"date":"2023-07-29T15:49:27","date_gmt":"2023-07-29T15:49:27","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4784"},"modified":"2023-08-01T15:59:48","modified_gmt":"2023-08-01T15:59:48","slug":"west-african-journal-of-pharmacy-2016-27-1-33-41","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2016-27-1-33-41\/","title":{"rendered":"West African Journal of Pharmacy (2016) 27 (1) 33-41"},"content":{"rendered":"\t\t
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Impact of highly active antiretroviral therapy on liver function of under-five\u00a0<\/b>HIV-positive children in Southern Nigeria<\/b><\/p>

\u00a0<\/b><\/p>

\u00a0Olugbenga M. Ajulo , Kayode M. Omole , Olanrewaju J. Moody , Ofonime T. Dixon-Umo and Lekan O. Salami<\/p>

1Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo,<\/span><\/p>

Uyo. Akwa-Ibom State. Nigeria.<\/span><\/p>

\u00a0<\/p>

2Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan,<\/span><\/p>

Ibadan. Oyo state. Nigeria.<\/p>

\u00a0<\/p>

3\u00a0Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan. Oyo State. Nigeria.<\/span><\/p>

4\u00a0Department of Pediatrics, Faculty of Clinical Sciences, College of Medicine, University of Uyo Teaching<\/span><\/p>

Hospital,Uyo. Akwa-Ibom State. Nigeria.<\/span><\/p>

\u00a0<\/p>

5\u00a0Pediatric PEPFAR clinic, University College Hospital, Ibadan. Oyo state. Nigeria.<\/span><\/p>

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Corresponding author: Olugbenga Ajulo<\/p>

E-mail: ajugbeng@gmail.com Phone: +2347030262468<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Hepatotoxicity deserves serious attention due to mortality, morbidity and treatment\u00a0discontinuation in HIV-seropositive patients.<\/span><\/p>

Objectives:<\/b> The study aimed at evaluating the impacts of Highly Active Antiretroviral Therapy (HAART) on liver\u00a0function of under-five children in Southern Nigeria.<\/span><\/p>

Method:<\/b> In five hospitals, 238 under-five children were enrolled after ethical permission was received from\u00a0Ethics and Research committees and written consent were obtained from participants’ care-givers.\u00a0<\/span>Participants were divided into six groups: the HIV-seropositive either on HAART (group A, n= 91) or co-<\/span>trimoxazole (group B, n= 11) and four other groups who were HIV-seronegative. Among this second cohort\u00a0<\/span>were those commenced on nevirapine for six weeks post-exposure (group C1, n= 24) and co-trimoxazole at 6\u00a0<\/span>months (group C2, n= 18) or 18 months (group C3, n= 48) post-exposure. The last group received no medication\u00a0<\/span>(group D, n= 46). Initially, a blood sample of 2ml was obtained from each participant and was assayed for\u00a0<\/span>alanine aminotransferase (ALT) and aspartate aminotransferase (AST). After three- and six-months from the\u00a0<\/span>time of initial study, only group A participants were restudied for the liver enzymes’ assay. Body mass index of\u00a0<\/span>the participants were also determined. Mean and standard deviation of the parameters of participants in group\u00a0<\/span>A was compared with those from other groups by using ANOVA. The differences in the parameters were\u00a0<\/span>considered significant at p \u22640.05.<\/span><\/p>

Results:<\/b> Alanine aminotransferase (ALT) was significantly higher in group A compared to group B (12.8\u00b111.0\u00a0IU\/L vs 6.5\u00b12.6 IU\/L, p= 0.245), group C1 (12.8\u00b111.0 IU\/L vs 10.9\u00b17.8 IU\/L, p= 0.910), group C2 (12.8\u00b111.0 IU\/L\u00a0<\/span>vs 11.7\u00b120.7 IU\/L, p= 0.995), group C3 (12.8\u00b111.0 IU\/L vs 11.2\u00b16.9 IU\/L, p= 0.868), and group D (12.8\u00b111.0 IU\/L\u00a0<\/span>vs 5.8\u00b13.4 IU\/L, p= 0.001). After three and six months of monitoring, ALT of group A was significantly decreased\u00a0<\/span>by 39.3% (p= 0.001) and 50.6% (p= 0.000) respectively.<\/span><\/p>

Conclusion:<\/b> The elevated ALT of under-five HIV-infected children on HAART lowered after six months of\u00a0monitoring.<\/span><\/p>

Keywords:<\/b> Under-five HIV children, Alanine aminotransferase, Aspartate aminotransferase,\u00a0Highly Active Antiretroviral Therapy.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Impact of highly active antiretroviral therapy on liver function of under-five\u00a0HIV-positive children in Southern Nigeria \u00a0 \u00a0Olugbenga M. Ajulo , Kayode M. Omole , Olanrewaju J. Moody , Ofonime T. Dixon-Umo and Lekan O. Salami 1Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo, Uyo. Akwa-Ibom State. Nigeria. \u00a0 2Department of Clinical […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[226],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4784"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4784"}],"version-history":[{"count":10,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4784\/revisions"}],"predecessor-version":[{"id":4796,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4784\/revisions\/4796"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4784"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4784"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}