{"id":4836,"date":"2023-07-23T15:19:58","date_gmt":"2023-07-23T15:19:58","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4836"},"modified":"2023-08-02T15:30:13","modified_gmt":"2023-08-02T15:30:13","slug":"west-african-journal-of-pharmacy-2016-27-1-104-117","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2016-27-1-104-117\/","title":{"rendered":"West African Journal of Pharmacy (2016) 27 (1) 104-117"},"content":{"rendered":"\t\t
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Formulation and characterization of gellan\u2013DEAE-dextran polyelectrolyte complex hydrogels<\/b><\/p>

\u00a0<\/b><\/p>

\u00a0<\/b><\/p>

Adeola T. Kola-Mustapha and Amos O. Abioye .<\/p>

1Faculty of Pharmaceutical Sciences University of Ilorin, Ilorin, Nigeria;<\/span><\/p>

2Leicester School of Pharmacy, De Montfort University, Leicester, UK.<\/span><\/p>

\u00a0<\/span><\/p>

Corresponding Author: Dr Adeola T. Kola-Mustapha<\/p>

Email: atkmusty@yahoo.com Phone: +2348033475485<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> There is a need to formulate hydrogels via direct physical interaction to circumvent the use of\u00a0crosslinker which can affect the integrity of the entrapped drug in the hydrogel.<\/span><\/p>

Objective:<\/b> The aim of this study is to formulate and characterise plain polyelectrolyte complex (PEC) hydrogels\u00a0prepared by physical interaction between gellan gum and oppositely charged DEAE-Dextran.<\/span><\/p>

Method:<\/b> Gellan-DEAE-Dextran (GDD) PEC hydrogels were prepared by polyelectrolyte complexation of gellan\u00a0and DEAE-Dextran. The GDD-PEC hydrogels were characterized using Scanning Electron Microscopy (SEM),\u00a0<\/span>Fourier Transform Infrared Spectroscopy (FTIR), Differential Scanning Calorimetry (DSC) and\u00a0<\/span>Thermogravimetric Analysis (TGA). Their swelling kinetics and rheological properties were also evaluated.<\/span><\/p>

Results:<\/b> Morphological characteristics analysed by SEM of plain gellan (G) hydrogel showed strand-like\u00a0smooth compact structured surface while the GDD-PEC hydrogels exhibited crinkled rough surfaces. The shifts\u00a0<\/span>and disappearances in peaks shown in the FTIR spectra, suggested an interaction between gellan and DEAE-<\/span>Dextran. DSC showed that the gellan and DEAE-Dextran merged into a single endothermic melting peak\u00a0<\/span>between 99.8 and 115.3 C in the GDD-PEC hydrogels. Their TGA showed that the plain gellan (G) hydrogel was\u00a0<\/span>able to withstand more heat when compared to the GDD-PEC hydrogels. The GDD-PEC hydrogels exhibited\u00a0<\/span>pseudoplastic and elastic characteristics based on the concentration of DEAE-Dextran. The addition of DEAE-<\/span>Dextran to GDD-PEC hydrogels significantly increased (p < 0.05, n = 4) their swelling ratio when compared to\u00a0<\/span>the plain gellan (G) hydrogel.<\/span><\/p>

Conclusion:<\/b> GDD-PEC hydrogels were successfully formulated and characterised. This formulation has the\u00a0potential for use in transdermal drug delivery systems.<\/span><\/p>

Keywords:<\/b> gellan, DEAE-Dextran, binary, polyelectrolyte complexation, hydrogels<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Formulation and characterization of gellan\u2013DEAE-dextran polyelectrolyte complex hydrogels \u00a0 \u00a0 Adeola T. Kola-Mustapha and Amos O. Abioye . 1Faculty of Pharmaceutical Sciences University of Ilorin, Ilorin, Nigeria; 2Leicester School of Pharmacy, De Montfort University, Leicester, UK. \u00a0 Corresponding Author: Dr Adeola T. Kola-Mustapha Email: atkmusty@yahoo.com Phone: +2348033475485 ABSTRACT Background: There is a need to formulate […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[226],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4836"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4836"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4836\/revisions"}],"predecessor-version":[{"id":4842,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4836\/revisions\/4842"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4836"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4836"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4836"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}