{"id":4857,"date":"2023-07-20T15:44:28","date_gmt":"2023-07-20T15:44:28","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4857"},"modified":"2023-08-02T15:51:10","modified_gmt":"2023-08-02T15:51:10","slug":"west-african-journal-of-pharmacy-2016-27-1-135-144","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2016-27-1-135-144\/","title":{"rendered":"West African Journal of Pharmacy (2016) 27 (1) 135-144"},"content":{"rendered":"\t\t
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Chemical and microbial analysis of different brands of Ibuprofen solid dosage formulations\u00a0<\/b>sold in Ilorin, Kwara State<\/b><\/p>

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Kamaldeen Abu-Saeed and Jamiu O. Muslim<\/p>

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1Research Unit, Peace Standard Pharmaceutical Industries Limited, Ilorin. Nigeria<\/span><\/p>

2Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, University of Ilorin. Nigeria.<\/span><\/p>

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Corresponding author: Kamaldeen Abu-Saeed<\/p>

Email kamal.abusaeed@yahoo.com Phone +2348033898351<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background: <\/b>Fake and substandard drugs have embarrassed healthcare providers and eroded the confidence\u00a0of the public on healthcare delivery system. They have led to therapeutic failure, adverse effects and microbial\u00a0<\/span>resistance to drugs. Therefore, there is the need to routinely determine the quality of drugs in the market to\u00a0<\/span>ascertain that they are stable, efficacious and safe for consumption.<\/span><\/p>

Objective:<\/b> This work was aimed at carrying out chemical and microbiological analysis on thirteen brands of\u00a0Ibuprofen solid dosage formulations sold across licensed Pharmacies in Ilorin, Kwara state and comparing\u00a0<\/span>results with brand used as standard using t-test analysis.<\/span><\/p>

Methods:<\/b> Chemical analysis was done using titrimetric method as described by International Pharmacopeia\u00a0to determine the percentage contents of the active components of the various samples of Ibuprofen solid\u00a0<\/span>formulations. Microbiological analysis was done using pour plate method to determine bacteria and fungi\u00a0<\/span>counts of samples. Analysis was done using Statistical Package for Social Science (SPSS) computer software\u00a0<\/span>and p values less or equal 0.05 were considered statistically significant.<\/span><\/p>

Results:<\/b> The percentage content of Ibuprofen in two of the brands were below specification as stated in British\u00a0Pharmacopeia and United States Pharmacopeia. These two brands were foreign brands. One of these two\u00a0<\/span>brands failed the microbiological analysis in addition. Sample t-test analysis showed that all but one of the test\u00a0<\/span>samples varied significantly (p \u2264 0.05) in terms of percentage content of Ibuprofen from sample used as\u00a0<\/span>standard.<\/span><\/p>

Conclusion:<\/b> Generally, majority of the various brands of Ibuprofen samples examined complied with official\u00a0standards.<\/span><\/p>

Keywords:<\/b> Ibuprofen, Chemical analysis, Microbiological analysis, Ilorin, Fake\/Substandard drugs.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Chemical and microbial analysis of different brands of Ibuprofen solid dosage formulations\u00a0sold in Ilorin, Kwara State \u00a0 Kamaldeen Abu-Saeed and Jamiu O. Muslim \u00a0 1Research Unit, Peace Standard Pharmaceutical Industries Limited, Ilorin. Nigeria 2Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, University of Ilorin. Nigeria. \u00a0 Corresponding author: Kamaldeen Abu-Saeed Email kamal.abusaeed@yahoo.com Phone +2348033898351 ABSTRACT […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[226],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4857"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4857"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4857\/revisions"}],"predecessor-version":[{"id":4863,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4857\/revisions\/4863"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4857"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4857"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4857"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}