{"id":4885,"date":"2023-08-03T13:58:02","date_gmt":"2023-08-03T13:58:02","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4885"},"modified":"2023-08-03T14:05:58","modified_gmt":"2023-08-03T14:05:58","slug":"west-african-journal-of-pharmacy-2015-26-2-1-14","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2015-26-2-1-14\/","title":{"rendered":"West African Journal of Pharmacy (2015) 26 (2) 1-14"},"content":{"rendered":"\t\t
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Formulation and physical characterization of Ibuprofen\u2013DEAE-Dextran\u00a0<\/b>nanoconjugates via Surfactant Solubilization<\/b><\/p>

\u00a0<\/p>

Adeola T. Kola-Mustapha , and Amos O. Abioye .<\/p>

1Faculty of Pharmaceutical Sciences University of Ilorin, Ilorin, Nigeria;<\/span><\/p>

\u00a0<\/p>

2Leicester School of Pharmacy, De Montfort University, Leicester, UK.<\/span><\/p>

\u00a0<\/span><\/p>

Corresponding author: Adeola Kola-Mustapha<\/p>

Email: atkmusty@yahoo.com Phone: +2348033475485<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background: <\/b>The optimization of polymer-drug conjugate design is important in effective and efficient delivery of poorly soluble drugs.<\/span><\/p>\n

Objectives:<\/b> This work focuses on the formulation of novel amorphous ibuprofen-polymer nanoconjugates based on the polymer-drug complexation in order to improve its physical characteristics in the absence of toxic <\/span>organic solvents.<\/span><\/p>\n

Methods:<\/b> Amorphous Ibuprofen \u2013 DEAE-Dextran nanoconjugates were prepared using surfactant solubilization method. Physical characterization of the nanoconjugates was carried out via conductivity, surface tension, <\/span>viscosity, transmittance\/turbidity, particle size measurement, zeta potential, conjugation efficiency and <\/span>Scanning Electron Microscopy (SEM) techniques.<\/span><\/p>\n

Results<\/b>: A remarkably high loading capacity was achieved ranging from 89.05 to 96.34%. The conductivity measurements showed that the critical association concentration (cac) was exhibited at 2.34 mg\/mL and critical <\/span>micellar concentration (cmc) at 8.0 mg\/mL. The presence of DEAE-Dextran decreased the cac of ibuprofen <\/span>significantly (p < 0.05, n = 6) confirming the electrostatic interaction between DEAE-Dextran and ibuprofen. <\/span>DEAE-Dextran showed surface activity and were adsorbed significantly at the water surface. The surface <\/span>morphologies of the nanoconjugates singly and in aggregates were all spherical in shape. The formulation of <\/span>ibuprofen-DEAE-Dextran conjugate reduced the size of ibuprofen (2.87 \u03bcm) significantly to 13.02 nm (268-fold) <\/span>-2 <\/span>at 1.6% (3.2 x 10 mM) DEAE-Dextran concentration. The zeta potential values obtained were relatively low (-<\/span>3.04 to +13.87 mV) indicating low repulsion stabilization.<\/span><\/p>\n

Conclusion:<\/b> This work shows the formulation of amorphous ibuprofen-DEAE-Dextran nanoconjugates via the surfactant solubilization with the potential of improving the delivery of ibuprofen.<\/span><\/p>\n

KeyWords<\/b>: Ibuprofen, surfactant solubilization, DEAE-Dextran and nanoconjugate<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Formulation and physical characterization of Ibuprofen\u2013DEAE-Dextran\u00a0nanoconjugates via Surfactant Solubilization \u00a0 Adeola T. Kola-Mustapha , and Amos O. Abioye . 1Faculty of Pharmaceutical Sciences University of Ilorin, Ilorin, Nigeria; \u00a0 2Leicester School of Pharmacy, De Montfort University, Leicester, UK. \u00a0 Corresponding author: Adeola Kola-Mustapha Email: atkmusty@yahoo.com Phone: +2348033475485 ABSTRACT Background: The optimization of polymer-drug conjugate design […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[224],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4885"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4885"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4885\/revisions"}],"predecessor-version":[{"id":4891,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4885\/revisions\/4891"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}