{"id":4917,"date":"2023-07-30T14:45:13","date_gmt":"2023-07-30T14:45:13","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4917"},"modified":"2023-08-03T14:58:13","modified_gmt":"2023-08-03T14:58:13","slug":"west-african-journal-of-pharmacy-2015-26-2-52-65","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2015-26-2-52-65\/","title":{"rendered":"West African Journal of Pharmacy (2015) 26 (2) 52-65"},"content":{"rendered":"\t\t
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Antimicrobial and antioxidant activities of methanolic leaf extract of Argemone mexicana linn (papaveraceae)<\/b><\/p>

\u00a0<\/p>

Aminat A. Oyawaluja , Adedolapo A. Obisesan , Olukemi A. Odukoya , Herbert A. B. Coker<\/p>

1Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos.<\/span><\/p>

2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos.<\/span><\/p>

\u00a0<\/p>

Corresponding author: Aminat Oyawaluja<\/p>

Email: aomidiji@unilag.edu.ng Phone: 08082143073<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Medicinal plants are well-known natural sources of remedies used in the treatment of innumerable disease since antiquity. The search for newer synthetic drugs is of immense importance due to <\/span>the increasing development of resistance. Antioxidant assay is a very useful technique in identifying plants <\/span>which contain antioxidants which are substances that delay or inhibits oxidative damage to a target molecule <\/span>thereby preventing the occurrence of degenerative diseases.<\/span><\/p>

Objectives<\/b>: To authenticate the local use of Argemone mexicana as a wound healing agent and evaluate its antimicrobial properties against various micro-organisms in comparison with standard antimicrobial agent.<\/span><\/p>

Method:<\/b> Antimicrobial assay was carried out against four bacterial strains and three fungi strains using the agar well diffusion method. The formation of a clear zone of inhibition was observed and measured and <\/span>compared with that of the standard. Antioxidant assay was carried out using the DPPH (1,1-diphenyl-2-picryl <\/span>hydrazyl) free radical scavenging activity. The absorbance was read at 517nm.<\/span><\/p>

Result:<\/b> The leaf extract of A.mexicana inhibit the growth of Pseudomonas aeruginosa and Staphylococcus aureus. The plant tested positive for phenols, tannins, flavonoids, alkaloids, resins, saponins and sugars. The <\/span>antioxidant assay indicates that the extract has a high percentage inhibition DPPH as compared with the <\/span>standard.<\/span><\/p>

Conclusion:<\/b> A. mexicana has been shown to inhibit the growth of some micro-organisms and could be useful in the treatment of infections caused by these organisms including pathogenic infections. Its antibacterial <\/span>potentials therefore confirm its use as wound healing. The plant possesses antioxidant activities due to the <\/span>presence of flavonoids and phenolic substances which help to fight against free radicals that cause certain <\/span>diseases in the body.<\/span><\/p>

Keywords:<\/b> Argemone mexicana, phytochemical screening, antioxidant, antimicrobial, percentage inhibition<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Antimicrobial and antioxidant activities of methanolic leaf extract of Argemone mexicana linn (papaveraceae) \u00a0 Aminat A. Oyawaluja , Adedolapo A. Obisesan , Olukemi A. Odukoya , Herbert A. B. Coker 1Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos. 2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Lagos. \u00a0 Corresponding author: Aminat Oyawaluja Email: […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[224],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4917"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4917"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4917\/revisions"}],"predecessor-version":[{"id":4923,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4917\/revisions\/4923"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4917"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4917"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4917"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}