{"id":4952,"date":"2023-07-25T15:29:33","date_gmt":"2023-07-25T15:29:33","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4952"},"modified":"2023-08-03T15:36:04","modified_gmt":"2023-08-03T15:36:04","slug":"west-african-journal-of-pharmacy-2015-26-2-103-115","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2015-26-2-103-115\/","title":{"rendered":"West African Journal of Pharmacy (2015) 26 (2) 103-115"},"content":{"rendered":"\t\t
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Antiretrovirals and co-prescribed drugs for people living with HIV\/AIDS (PLWHA)\u00a0<\/b>in a university teaching hospital, south west Nigeria<\/b><\/p>

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Sulaimon A. Akanmu Sikiru O. Usman , Ibrahim A. Oreagba , Oluwatoyin E. Agbaje , Kazeem Oshikoya,\u00a0Abideen A. Ganiyu and Oluwatoyin O. Opanuga .<\/span><\/p>

\u00a0<\/p>

1Department of Haematology and Blood Transfusion, College of Medicine of the University of Lagos.<\/span><\/p>

2APIN Clinic, Lagos University Teaching Hospital (LUTH), Idiaraba, Lagos, Nigeria<\/span><\/p>

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3Department of Pharmacology, Therapeutics & Toxicology, College of Medicine of the University of Lagos<\/span><\/p>

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4West African Postgraduate College of Pharmacists, Yaba, Lagos State, Nigeria<\/span><\/p>

5National Agency for Food and Drug Administration and Control<\/span><\/p>

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6Department of Pharmacology, Lagos State University Teaching Hospital (LASUTH), Ikeja.<\/span><\/p>

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Corresponding Author: Usman Sikiru<\/p>

E-mail: susman@unilag.edu.ng Phone : +2347066263713<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background: <\/b>Lifelong usage of antiretroviral drugs (ARVs) put them among the most therapeutically risky drugs for clinically significant drug interactions (CSDIs). It is, therefore, essential to document the types of <\/span>antiretroviral (ARV) and non-ARV drugs co-prescribed (CPD) for PLWHA in order to facilitate the assessment of <\/span>clinical significance of their interactions.<\/span><\/p>

Objectives:<\/b> To document the most commonly prescribed ARV drugs and CPD among PLWHA and to assess the frequency of prescriptions of the first, second and third lines ART regimen.<\/span><\/p>

Methods:<\/b> All the prescriptions received between January 2009 and June 2014 totaling 22,458 from 500 patients registered in APIN clinic in 2009, were reviewed with a view to documenting the most and the least <\/span>prescribed CPD and ARV drugs.<\/span><\/p>

Results:<\/b> Zidovudine\/lamivudine\/nevirapine (AZT\/3TC\/NVP) (4996\/9302; 53.71%) was the most commonly prescribed ART regimen followed by tenofovir\/emtricitabine\/efavirenz (TDF\/FTC\/EFV) (1468\/9302;<\/span>15.78%)and zidovudine\/lamivudine\/efavirenz (AZT\/3TC\/EFV) (683\/9302; 7.34%). <\/span>Abacavir\/lamivudine\/saquinavir\/ritonavir (ABC\/3TC (SQV\/RTV) (1\/9302; 0.01%) was the least prescribed ART <\/span>regimen. The first line ART regimens (8574\/9302; 92.17%) were mostly prescribed, followed by the second line <\/span>(698\/9302; 9.5%). Cotrimoxazole (7546\/9302; 81.12%) was the most common non-ARV drug co-prescribed <\/span>with ART regimen, followed by multivitamin (433\/9302; 4.65%) and rifampin (316\/9302; 3.40%).<\/span><\/p>

Conclusion:<\/b> Co-trimoxazole was the most commonly co-prescribed non-ARV drug. Zidovudine\/lamivudine\/nevirapine was the most commonly prescribed ART regimen. Considering the wide range of non-<\/span>ARV drugs co-prescribed with ART regimens in this study, evaluation of their potential interactions is hereby <\/span>suggested.<\/span><\/p>

Keywords:<\/b> Co-prescribed drugs, HIV treatment regimen, antiretrovirals, non-antiretrovirals<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Antiretrovirals and co-prescribed drugs for people living with HIV\/AIDS (PLWHA)\u00a0in a university teaching hospital, south west Nigeria \u00a0 Sulaimon A. Akanmu Sikiru O. Usman , Ibrahim A. Oreagba , Oluwatoyin E. Agbaje , Kazeem Oshikoya,\u00a0Abideen A. Ganiyu and Oluwatoyin O. Opanuga . \u00a0 1Department of Haematology and Blood Transfusion, College of Medicine of the University […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[224],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4952"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4952"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4952\/revisions"}],"predecessor-version":[{"id":4958,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4952\/revisions\/4958"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4952"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4952"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4952"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}