{"id":4983,"date":"2023-08-02T15:51:48","date_gmt":"2023-08-02T15:51:48","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4983"},"modified":"2023-08-03T15:59:10","modified_gmt":"2023-08-03T15:59:10","slug":"west-african-journal-of-pharmacy-2015-26-1-11-20","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2015-26-1-11-20\/","title":{"rendered":"West African Journal of Pharmacy (2015) 26 (1) 11-20"},"content":{"rendered":"\t\t
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Knowledge of caregivers of febrile children about fever, paracetamol use and\u00a0<\/b>paracetamol induced hepatic toxicity in Lagos Nigeria.<\/b><\/p>

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Obiyo Nwaiwu , Akinwumi Akinyede and Nkechi Okafor.<\/p>

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1Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos.<\/span><\/p>

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2Onwusikawa Children’s Medical Centre, Ago Okota, Lagos, Nigeria.<\/span><\/p>

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Corresponding author: Obiyo Nwaiwu<\/p>

Email: onwaiwu@unilag.edu.ng Phone: +2348037790925<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background: <\/b>Fever is as a result of immune response to many pathogens. Paracetamol is widely and\u00a0irrationally used at home for treatment of fever in children before presentation at the health facility but it is not\u00a0<\/span>clear whether caregivers are aware of the toxicity that can result from non-rational use of paracetamol.<\/span><\/p>

Objectives:<\/b> The aim of this study was to evaluate the knowledge of fever, the use of paracetamol, and\u00a0paracetamol induced hepatic toxicity amongst caregivers of febrile children.<\/span><\/p>

Methods:<\/b> This was a prospective descriptive study in which we interviewed two hundred and ten\u00a0caregivers who brought febrile children to Onwusikawa Children’s Medical Center Okota Lagos over a\u00a0<\/span>period of one year (Jan 2013- Dec 2013). A pretested closed ended questionnaire was used to collect data on\u00a0<\/span>the use of paracetamol, knowledge about fever, and toxicity of paracetamol during routine clerking.<\/span><\/p>

Result:<\/b> Paracetamol in both syrup and tablet formulations was administered by the study population to\u00a0febrile children before presentation in hospital . Majority of the respondents (61%) knew fever as an\u00a0<\/span>increase in body temperature. About 8% of those interviewed gave paracetamol to their children including\u00a0<\/span>neonates almost on a daily basis to prevent fever or because they felt the baby especially the head was hot.\u00a0<\/span>Ninety five percent of all respondents were not aware that paracetamol could cause adverse effects while 98%\u00a0<\/span>did not know that paracetamol could cause hepatic toxicity.<\/span><\/p>

Conclusion:<\/b> The knowledge regarding toxicity of paracetamol was poor. It is proposed that education of\u00a0caregivers by health workers on dangers of paracetamol misuse should be routine. Pharmaceutical companies\u00a0<\/span>that manufacture paracetamol for children must provide a risk management plan.<\/span><\/p>

Key words:<\/b> Paracetamol, caregiver, febrile children, liver toxicity.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Knowledge of caregivers of febrile children about fever, paracetamol use and\u00a0paracetamol induced hepatic toxicity in Lagos Nigeria. \u00a0 Obiyo Nwaiwu , Akinwumi Akinyede and Nkechi Okafor. \u00a0 1Department of Pharmacology, Therapeutics and Toxicology, College of Medicine, University of Lagos. \u00a0 2Onwusikawa Children’s Medical Centre, Ago Okota, Lagos, Nigeria. \u00a0 Corresponding author: Obiyo Nwaiwu Email: onwaiwu@unilag.edu.ng […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[234],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4983"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4983"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4983\/revisions"}],"predecessor-version":[{"id":4989,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4983\/revisions\/4989"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4983"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4983"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4983"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}