{"id":4990,"date":"2023-08-01T15:13:10","date_gmt":"2023-08-01T15:13:10","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4990"},"modified":"2023-08-04T15:24:30","modified_gmt":"2023-08-04T15:24:30","slug":"west-african-journal-of-pharmacy-2015-26-1-21-32","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2015-26-1-21-32\/","title":{"rendered":"West African Journal of Pharmacy (2015) 26 (1) 21-32"},"content":{"rendered":"\t\t
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Effects of highly active antiretroviral therapy on renal function of HIV-infected under-fives in Southern Nigeria<\/b><\/p>

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Olugbenga M. Ajulo , Kayode M. Omole , Olanrewaju J. Moody , Regina Oladokun , Ofonime T. Dixon-Umo<\/p>

1Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo,\u00a0<\/span>Uyo. AkwaIbom State. Nigeria.<\/span><\/p>

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2Department of Clinical Pharmacy and Pharmacy Administration,Faculty of Pharmacy, University of\u00a0<\/span>Ibadan, Ibadan. Oyo State. Nigeria.<\/span><\/p>

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3Department of Pharmacognosy, Faculty of Pharmacy, University of Ibadan, Ibadan. Oyo State. Nigeria.<\/span><\/p>

4Department of Pediatrics, Faculty of Medicine, College of Medicine, University College Hospital, Ibadan.\u00a0<\/span>Oyo State. Nigeria.<\/span><\/p>

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5Department of Pediatrics, Faculty of Medicine, College of Medicine ,University of Uyo Teaching Hospital,\u00a0<\/span>Uyo. Akwa-Ibom State. Nigeria.<\/span><\/p>

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Corresponding Author: Olugbenga M. Ajulo<\/p>

E-mail: ajugbeng@gmail.com Phone: +2347030262468<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Toxicities from antiretrovirals caused clinically-relevant organ damage.<\/p>

Objective: Study aimed at monitoring effects of Highly Active Antiretroviral Therapy (HAART) on kidney of\u00a0HIV-infected under-fives in Southern Nigeria.<\/span><\/p>

Methods: In Southern Nigeria, 238 under-fives were recruited. Institutional approval and written consent\u00a0were obtained. Group A consisted of 91 HIV-infected children on HAART. Group B1 consisted of 24 HIV-<\/span>exposed infants born to breast feeding HIV-mothers on HAART, who received nevirapine for first 6-week of\u00a0<\/span>life. Group B2 (18) and B3 (48) consisted of HIV-exposed children on co-trimoxazole at age 6-month and 18-\u00a0<\/span>month respectively. Group C consisted of 11 HIV-infected children on co-trimoxazole. Group D consisted of\u00a0<\/span>46 seronegative children. A 2ml blood was collected from each participant during first phase of the study and\u00a0<\/span>\u00ae was analysed for creatinine using Randox kits. Group A returned for second and third phase of the study after\u00a0<\/span>3 and 6 months respectively. Data was analysed by using ANOVA.\u00a0<\/span>2<\/span><\/p>

Results:<\/b> Creatinine clearance was highest in group A (102.6\u00b182.9ml\/min\/1.732m ) suggesting normal renal\u00a0<\/span>function. Second phase, creatinine clearance of group A was reduced by 8.7% (p>0.05). Third phase,\u00a0<\/span>creatinine clearance was reduced by 25.4% (p<0.05) suggesting reduced renal function.<\/span><\/p>

Conclusion:<\/b> HAART was significantly associated with reduced renal function among HIV-infected under-fives\u00a0in Southern Nigeria.<\/span><\/p>

Keywords:<\/b> Under-five HIV children; kidney; creatinine; creatinine clearance; HAART.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Effects of highly active antiretroviral therapy on renal function of HIV-infected under-fives in Southern Nigeria \u00a0 Olugbenga M. Ajulo , Kayode M. Omole , Olanrewaju J. Moody , Regina Oladokun , Ofonime T. Dixon-Umo 1Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, University of Uyo,\u00a0Uyo. AkwaIbom State. Nigeria. \u00a0 2Department of Clinical Pharmacy and […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[234],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4990"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4990"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4990\/revisions"}],"predecessor-version":[{"id":4996,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4990\/revisions\/4996"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4990"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4990"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4990"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}