{"id":4997,"date":"2023-07-31T15:26:17","date_gmt":"2023-07-31T15:26:17","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=4997"},"modified":"2023-08-04T15:47:34","modified_gmt":"2023-08-04T15:47:34","slug":"west-african-journal-of-pharmacy-2015-26-1-33-40","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2015-26-1-33-40\/","title":{"rendered":"West African Journal of Pharmacy (2015) 26 (1) 33-40"},"content":{"rendered":"\t\t
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Antimicrobial studies of the leaf extract of Argemone mexicana and its ointment formulation<\/b><\/p>

\u00a0<\/b><\/p>

Alayo A Muinat, Femi-Oyewo N Mbang, Bakre G Lateef, Temionu O Esther, Bamiro A Oluyemisi<\/p>

Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy,\u00a0Olabisi Onabanjo University, Nigeria.<\/span><\/p>

\u00a0<\/span><\/p>

Corresponding author: Lateef Bakre<\/p>

E- mail: lateefbakr@yahoo.com Phone: +2348033700102<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background: <\/b>Skin infections are rampant in children and there is a widespread resistance to common antibacterial and antifungal therapies for these infections.<\/span><\/p>\n

Objective:<\/b> This study aims to screen the extract of Argemone mexicana leaffor antibacterial and antifungal activity; and formulate the extract into ointment dosage forms using simple ointment B.P.C.<\/span><\/p>\n

Methods<\/b>: Preliminary phytochemical studies were performed and the methanol, ethanol and n-hexane leaf extracts of Argemone mexicana Linn. were evaluated for antimicrobial activity against some <\/span>pathogenic bacteria- Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumonia(Gram negative) and <\/span>Streptococcus spp, Staphylococcus aureus (Gram positive) and dermatophytes such as Trichophyton <\/span>mentagrophytes, Trichophyton rubrum, Microsporum audouinii (fungi) using well diffusion method. The <\/span>most active extract was formulated into ointment and evaluated for physicochemical and antimicrobial <\/span>activity.<\/span><\/p>\n

Results:<\/b> Flavonoids and alkaloids were present in all the extracts while anthraquinones and saponin were present in methanol and n hexane extract. The ranking for extract activity was methanol>n-hexane><\/span>ethanol. The methanol extract showed comparable activity with gentamicin against Staphylococcus aureus <\/span>and higher activity against Escherichia coli at 250mg\/ml and 500mg\/ml. The order of activity of the <\/span>methanol extract against the test organisms is Staphylococcus aureus> Escherichia coli> Streptococcus spp> <\/span>Klebsiella pneumonia> Trichophyton mentagrophyte> Trichophyton rubrums> Microsporum audouinii. <\/span>There was no significant variation (P> 0.05) in the zones of inhibition of bacteria with the methanol extract. <\/span>The formulated ointment had a characteristic odour, smooth texture, was easy to apply on rubbing, easy to <\/span>remove with soap and water and non-irritant on skin.<\/span><\/p>\n

Conclusion:<\/b> The result of this study supports the traditional uses of these plants and shows that the plant extract possesses antibacterial and antifungal activities<\/span><\/p>\n

Keywords:<\/b> Argemone mexicana, antibacterial activity, antifungal activities, phytochemical analysis, ointment formulation<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Antimicrobial studies of the leaf extract of Argemone mexicana and its ointment formulation \u00a0 Alayo A Muinat, Femi-Oyewo N Mbang, Bakre G Lateef, Temionu O Esther, Bamiro A Oluyemisi Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmacy,\u00a0Olabisi Onabanjo University, Nigeria. \u00a0 Corresponding author: Lateef Bakre E- mail: lateefbakr@yahoo.com Phone: +2348033700102 ABSTRACT Background: Skin infections […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[234],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4997"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=4997"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4997\/revisions"}],"predecessor-version":[{"id":5003,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/4997\/revisions\/5003"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=4997"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=4997"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=4997"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}