{"id":5040,"date":"2023-07-26T14:22:47","date_gmt":"2023-07-26T14:22:47","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=5040"},"modified":"2023-08-05T14:33:20","modified_gmt":"2023-08-05T14:33:20","slug":"west-african-journal-of-pharmacy-2015-26-1-79-87","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2015-26-1-79-87\/","title":{"rendered":"West African Journal of Pharmacy (2015) 26 (1) 79-87"},"content":{"rendered":"\t\t
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Antibiotic susceptibility profile of isolates from pregnant women with asymptomatic bacteriuria\u00a0<\/b>attending antenatal clinics in three hospitals in Kano, Nigeria<\/b><\/p>

Mojirayo T. Durowaiye , Josiah A. Onaolapo , Rukayat A. Oyi , James C. Igwe<\/p>

1 Department of Pharmaceutical Microbiology, University of Ibadan, Ibadan, Nigeria<\/p>

2 Department of Pharmaceutics and Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, Nigeria<\/p>

3Department of Medical Biotechnology, National Biotechnology Development Agency, Abuja, Nigeria<\/span><\/p>

\u00a0<\/p>

Corresponding Author: Mojirayo Durowaiye<\/p>

Email: mojihambolu@yahoo.com Phone: +2348065409700<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Pregnancy enhances the progression from asymptomatic to symptomatic bacteriuria which could lead to pyelonephritis and adverse obstetric outcomes. This study is aimed at determining the <\/span>prevalence of asymptomatic bacteriuria and antibiotic susceptibility testing of uropathogens from pregnant <\/span>women.<\/span><\/p>\n

Objectives:<\/b> This experimental study was done to determine the antibiotic susceptibility profile of uropathogens from antenatal patients.<\/span><\/p>\n

Method:<\/b> Three hundred and ten asymptomatic women attending antenatal clinics were sampled for thepresence of bacteria. Antibiotic susceptibility test of isolates were carried out using Kirby-Bauer disc <\/span>diffusion method.<\/span><\/p>\n

Result:<\/b> The prevalence of asymptomatic bacteriuria was found to be 15.2%, and Proteus spp (49.0%) the most prevalent organism. Antimicrobial susceptibility profile of Proteus spp. and E. coli to some commonly <\/span>prescribed antibiotics showed resistance to amoxicillin, ciprofloxacin, ceftriaxone, nitrofurantoin, <\/span>gentamicin, levofloxacin, cotrimoxazole, amoxicillin\/clavulanic acid, nalidixic acid and tetracycline (47-<\/span>100%). S. aureus showed resistance to ceftriaxone, nitrofurantoin, amoxicillin\/clavulanic acid, nalidixic acid <\/span>and tetracycline (66.7-100%). The multiple antibiotic resistance index (MARI) observed in this study with <\/span>reference to the tested antibiotics showed that 99.96% of the Proteus spp. isolates have MAR Index of 0.2 to <\/span>1.0, while 99.97% of the E. coli isolates have MAR Index of 0.2 to 1.0.<\/span><\/p>\n

Conclusion: <\/b>These call for rational use of antibiotics in antenatal clinics to limit the emergence and transmission of multiple antibiotic resistant strains, more so when there is a change of pattern in the <\/span>prevailing organism in asymptomatic bacteriuria which must be treated in pregnancy in order to prevent <\/span>adverse maternal and neonatal complications.<\/span><\/p>\n

Keywords:<\/b> Asymptomatic bacteriuria, multiple antibiotic resistance, pregnant women<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Antibiotic susceptibility profile of isolates from pregnant women with asymptomatic bacteriuria\u00a0attending antenatal clinics in three hospitals in Kano, Nigeria Mojirayo T. Durowaiye , Josiah A. Onaolapo , Rukayat A. Oyi , James C. Igwe 1 Department of Pharmaceutical Microbiology, University of Ibadan, Ibadan, Nigeria 2 Department of Pharmaceutics and Pharmaceutical Microbiology, Ahmadu Bello University, Zaria, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[234],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5040"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=5040"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5040\/revisions"}],"predecessor-version":[{"id":5046,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5040\/revisions\/5046"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=5040"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=5040"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=5040"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}