{"id":5140,"date":"2023-07-31T13:49:35","date_gmt":"2023-07-31T13:49:35","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=5140"},"modified":"2023-08-07T14:11:44","modified_gmt":"2023-08-07T14:11:44","slug":"west-african-journal-of-pharmacy-2014-25-2-54-75","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2014-25-2-54-75\/","title":{"rendered":"West African Journal of Pharmacy (2014) 25 (2) 54-75"},"content":{"rendered":"\t\t
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Lacagpregs- a group of novel multifunctional excipients:\u00a0<\/b>development and solid state characterization<\/b><\/p>

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Ebere I. Okoye , Anthony O. Onyekweli and Olobayo O. Kunle<\/p>

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1\u00a0Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences,\u00a0<\/span>Nnamdi Azikiwe University, Awka, Anambra State, Nigeria<\/span><\/p>

2\u00a0Department of Pharmaceutics and Pharmaceutical Technology,\u00a0<\/span>Faculty of Pharmacy University of Benin, Benin City, Edo State, Nigeria<\/span><\/p>

3\u00a0Department of Pharmaceutical Technology and Raw Materials Development,<\/span><\/p>

National Institute for Pharmaceutical Research and Development (NIPRD), Idu, Abuja, Nigeria<\/p>

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Corresponding author: Ebere I. Okoye<\/p>

Email: ei.okoye@unizik.edu.ng, Phone: +234(0)8052742521<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> The need for multifunctional excipients useable in wet granulation and direct compression\u00a0informed the quest for this study.<\/span><\/p>

Objective:<\/b> This study was aimed at developing multifunctional excipient series from which product(s) with\u00a0suitable characteristics for application in tablet production may be harnessed.<\/span><\/p>

Method:<\/b> A mixture of lactose and cashew gum solutions at 50 C was co-precipitated with chilled ethanol. A\u00a0dispersion of partially pregelatinized starch in ethanol was added to the co-precipitate and agitated using a\u00a0<\/span>planetary mixer operated at three arbitrary speed levels (L , L , L ) and time intervals (10, 30, 60 min) at 10\u00b11 C 1 2 3\u00a0<\/span>to generate the products. Granule size was homogenized by double screening through 600 \u03bcm sieve. The\u00a0<\/span>granules were characterized and the best product was used to formulate tablets by direct compression and\u00a0<\/span>wet granulation.<\/span><\/p>

Results: Agitating at the arbitrary speed, L , for 30 min was the optimum condition for generating the highest 2\u00a0excipient yield. FTIR revealed that interactions between primary constituents during the production process\u00a0<\/span>were physical. X-ray powder diffraction and DSC showed that higher agitator’s speed and\/or longer agitation\u00a0<\/span>time generated less crystalline products. The products differed in moisture sorption characteristics but the\u00a0<\/span>differences were not statistically significant. The less crystalline products displayed better deformation upon\u00a0<\/span>compaction with little or no voids. Tablets formulated with lacagpregs met official requirements on quality\u00a0<\/span>and compared without significant difference to those of similar tablets formulated with standard excipients.<\/span><\/p>

Conclusion: Lacagpregs, the products of this simple technique, may function as multifunctional excipients in\u00a0tablet formulation via wet granulation or direct compression.<\/span><\/p>

Keywords: Lacagpregs; Particle engineering; Novel multifunctional excipient; Direct compression; Wet\u00a0granulation.<\/span><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Lacagpregs- a group of novel multifunctional excipients:\u00a0development and solid state characterization \u00a0 Ebere I. Okoye , Anthony O. Onyekweli and Olobayo O. Kunle \u00a0 1\u00a0Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences,\u00a0Nnamdi Azikiwe University, Awka, Anambra State, Nigeria 2\u00a0Department of Pharmaceutics and Pharmaceutical Technology,\u00a0Faculty of Pharmacy University of Benin, Benin City, Edo State, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[235],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5140"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=5140"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5140\/revisions"}],"predecessor-version":[{"id":5146,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5140\/revisions\/5146"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=5140"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=5140"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=5140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}