{"id":5163,"date":"2023-07-27T14:40:36","date_gmt":"2023-07-27T14:40:36","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=5163"},"modified":"2023-08-07T14:53:42","modified_gmt":"2023-08-07T14:53:42","slug":"west-african-journal-of-pharmacy-2014-25-2-107-114","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2014-25-2-107-114\/","title":{"rendered":"West African Journal of Pharmacy (2014) 25 (2) 107-114"},"content":{"rendered":"\t\t
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Isolation of an Antibacterial Principle from Terminalia ivorensis chev. Stem bark<\/b><\/p>

\u00a0<\/p>

Babatunde B. Samuel, Philip A. Idowu , Ayo O. Aderibigbe and Adekola Y. Adekunle<\/p>

1* Bioorganic Chemistry Division, Indian Institute of Integrative Medicine, Jammu, India Pharmaceutical<\/p>

2 Microbiology Dept., Faculty of Pharmacy, University of Ibadan, Nigeria Pharmaceutical Chemistry Dept.,<\/p>

\u00a0<\/p>

3\u00a0Faculty of Pharmacy, University of Ibadan, Nigeria<\/span><\/p>

\u00a0<\/span><\/p>

Corresponding author: Babatunde B. Samuel<\/p>

Email: tundebsamuel@gmail.com Phone: +2348131951725<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> Widespread resistance to current antibiotic therapies has necessitated the search for new anti-infectives from natural and synthetic sources. Ethnobotanical information indicated the use of Terminalia <\/span>ivorensisin the treatment of wounds, syphilis and inflammation.<\/span><\/p>\n

Objectives<\/b>: This study was undertaken to investigate the antibacterial properties of the Terminalia ivorensis extract and isolate the bioactive compound from the extract.<\/span><\/p>\n

Methods:<\/b> Sensitivity of four nosocomial microorganisms (Bacillus substilis, Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus) to the acetone extract of T. Ivorensis was investigated by agar cup <\/span>diffusion method. Bioguided solvent\u2013solvent fractionation was carried out on the extract. The most active <\/span>fraction was subjected to open column chromatography to obtain a bioactive compound. The compound was <\/span>characterized by application of spectroscopic techniques (ESI-MS, HR-MS, 1D and 2D NMR).<\/span><\/p>\n

Results:<\/b> Four microorganisms were sensitive to the whole extract. Column separation led to the isolation of 2-(3,5-dihydroxyphenyl)-benzofuran-5,6-diol as an active principle in the extract. MIC values obtained for the <\/span>bioactive compound and the whole acetone extract were 1.25mg\/ml and 12.5mg\/ml respectively.<\/span><\/p>\n

Conclusion:<\/b> This study suggests that there is a scientific basis for the application of T. ivorensis extract in the treatment of infections. Further studies on its in vivo activities and the toxicity profile are required before <\/span>application in humans.<\/span><\/p>\n

Keywords:<\/b> Terminalia ivorensis,nosocomial microorganisms, 2-(3,5-dihydroxyphenyl)-benzofuran-5,6-diol.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Isolation of an Antibacterial Principle from Terminalia ivorensis chev. Stem bark \u00a0 Babatunde B. Samuel, Philip A. Idowu , Ayo O. Aderibigbe and Adekola Y. Adekunle 1* Bioorganic Chemistry Division, Indian Institute of Integrative Medicine, Jammu, India Pharmaceutical 2 Microbiology Dept., Faculty of Pharmacy, University of Ibadan, Nigeria Pharmaceutical Chemistry Dept., \u00a0 3\u00a0Faculty of Pharmacy, […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[235],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5163"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=5163"}],"version-history":[{"count":7,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5163\/revisions"}],"predecessor-version":[{"id":5172,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5163\/revisions\/5172"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=5163"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=5163"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=5163"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}