{"id":5310,"date":"2023-07-28T08:49:06","date_gmt":"2023-07-28T08:49:06","guid":{"rendered":"https:\/\/wapcpharm.org\/journal\/?p=5310"},"modified":"2023-08-08T08:56:48","modified_gmt":"2023-08-08T08:56:48","slug":"west-african-journal-of-pharmacy-2012-23-2-87-97","status":"publish","type":"post","link":"https:\/\/wapcpharm.org\/journal\/west-african-journal-of-pharmacy-2012-23-2-87-97\/","title":{"rendered":"West African Journal of Pharmacy (2012) 23 (2) 87 \u2013 97"},"content":{"rendered":"\t\t
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Health-Related Quality of Life and CD4 cells status of Patients receiving\u00a0Antiretroviral Therapy in Nigeria<\/span><\/b><\/p>

\u00a0<\/p>

Kenneth Anene Agu ; Obehi Okojie ; Dorothy A. N. Oqua , Rosalyn C King , Muhammadu A Isah,\u00a0Paul Gerald Iyaji , Olumuyiwa Omonaiye , Chamberlin Onuoha , Anthony K. Wutoh<\/span><\/p>

\u00a0<\/p>

3\u00a0Nigeria, Howard University PACE Center, Washington DC, USA<\/span><\/p>

Howard University PACE Center, Abuja, Nigeria, University of Benin, Benin,<\/span><\/p>

\u00a0<\/p>

Corresponding Author: Kenneth Anene Agu<\/p>

Email: agkenneth@gmail.com, Phone Number: +2348033031467<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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ABSTRACT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Background:<\/b> The goals of antiretroviral therapy (ART) are to improve patient’s health-related quality of\u00a0life (HRQOL) and restore immunologic function among others.<\/span><\/p>

Objectives<\/b>: The study evaluated HRQOL and CD4-cells response of HIV-infected patients at months 0\u00a0and 6 of receiving ART in Maitama District Hospital Abuja, Nigeria.<\/span><\/p>

Methods<\/b>: HRQOL of a cohort of 150 HIV-infected patients was evaluated at months 0 and 6 of receiving\u00a0ART using Medical Outcomes Study Short Form-36 (MOS SF-36) which has 8 domains. These include\u00a0<\/span>physical functioning, physically and emotionally related role limitations, social functioning, pain,\u00a0<\/span>energy\/fatigue, emotional well-being and general health. A paired samples t-test was used to compare\u00a0<\/span>the HRQOL scores and CD4 cells count of participants at months 0 and 6. Wilcoxon’s signed-ranks test\u00a0<\/span>was used to compare HRQOL of male and female participants. At two-tailed test, p value of <0.05 was\u00a0<\/span>considered significant.<\/span><\/p>

Results<\/b>: The mean age (\u00b1SD) of the 150 participants at ART initiation was 34.3 \u00b1 8.4 years; 59.3% were\u00a0females. The mean (\u00b1SD) HRQOL of participants increased significantly from 71.9% \u00b1 20.9 at ART\u00a0<\/span>initiation to 89.7% \u00b1 10.6 after 6 months of ART (p<0.05). The change in all SF-36 domains was\u00a0<\/span>statistically significant (p<0.05) except for the domains of role limitation due to emotional problems,\u00a0<\/span>social functioning and pain. The improvement in the mental component score (MCS) was significant\u00a0<\/span>(p<0.05) unlike that of the physical component (PCS). The difference in the HRQOL of male and female\u00a0<\/span>participants at months 0 and 6 was not significant. The mean CD4 cell count (\u00b1SD) increased from 185.7\u00a0<\/span>\u00b191.0 cells\/mm3 at month 0 to 199.0 \u00b1104.7 cells\/mm3 after 6months of ART; though this increase was\u00a0<\/span>not statistically significant.<\/span><\/p>

Conclusion<\/b>: There was significant improvement in the mean HRQOL scores of participants which was\u00a0not associated with significant improvement in the CD4 cells status after six months of ART. The\u00a0<\/span>evaluation of HRQOL alongside the clinical and immunological parameters when monitoring\u00a0<\/span>treatment outcomes is recommended.<\/span><\/p>

Key words<\/b>: HIV\/AIDS, Antiretroviral therapy, Outcomes, Quality of Life, Nigeria<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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\n\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\tDownload <\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Health-Related Quality of Life and CD4 cells status of Patients receiving\u00a0Antiretroviral Therapy in Nigeria \u00a0 Kenneth Anene Agu ; Obehi Okojie ; Dorothy A. N. Oqua , Rosalyn C King , Muhammadu A Isah,\u00a0Paul Gerald Iyaji , Olumuyiwa Omonaiye , Chamberlin Onuoha , Anthony K. Wutoh \u00a0 3\u00a0Nigeria, Howard University PACE Center, Washington DC, USA […]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[237],"tags":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5310"}],"collection":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/comments?post=5310"}],"version-history":[{"count":4,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5310\/revisions"}],"predecessor-version":[{"id":5316,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/posts\/5310\/revisions\/5316"}],"wp:attachment":[{"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/media?parent=5310"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/categories?post=5310"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/wapcpharm.org\/journal\/wp-json\/wp\/v2\/tags?post=5310"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}