Year : 2023 | Volume : 34 | Issue : 1 | Page : 1-14
Exacerbation of motor and non-motor symptoms of Parkinson disease by severe acute respiratory syndrome-coronavirus-2 infection: Are there possible links?
Ismail O. Ishola , Taiwo G. Olubodun-Obadun , Rachael O. Folarin , Olufunmilayo O. Adeyemi
1Department of Pharmacology, Therapeutics and Toxicology, Faculty of Basic Medical Sciences,
College of Medicine, University of Lagos, Lagos State, Nigeria.
2Department of Veterinary Anatomy, University of Ibadan, Ibadan Oyo State, Nigeria.
Corresponding author: Ismail O. Ishola
Email: oishola@cmul.edu.ng
Telephone: +2348033018908
ABSTRACT
Background: Parkinson’s disease (PD) is an ageing and progressive neurological disorder characterized by both motor (tremors, bradykinesia, rigidity) and non-motor symptoms (depression, GI disturbance, and cognitive decline). COVID-19 is a highly infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) with symptoms ranging from mild to severe cardiopulmonary dysfunction. Moreover, COVID-19 infection causes excessive release of pro inflammatory cytokines and gut microbiome alterations and has been reported to cause neurological complications, all of which are more prevalent in PD.